Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare Abiraterone (Zytiga) and Enzalutamide (Xtandi) — clinical data, side effects, and patient experiences.
Zytiga · CYP17 Inhibitor
How it works
Inhibits CYP17A1 enzyme, blocking androgen biosynthesis in testicular, adrenal, and tumor tissues.
Approved for
Xtandi · Androgen Receptor Inhibitor
How it works
Potent androgen receptor signalling inhibitor that blocks testosterone binding, AR nuclear translocation, and DNA binding.
Approved for
Estimated frequency (%) based on clinical trial data
Based on 14 Reddit discussions
Abiraterone
50%
positive
8 threads
Enzalutamide
83%
positive
6 threads
% of discussions mentioning each side effect
8 Reddit threads analysed for Abiraterone
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
29 upvotes
Most discussed side effects in community
Powers love to talk about "DHT mutants", for transwomen with a high DHT despite good or high doses of E, and sometimes proper AA treatment too, with either normal, low, or very low T ; for which he thinks the prevalence is like 1/30: /r/DrWillPowers/comments/jbbcbi/today_i_saw_the_worst_dht_mutant_i
Late 60s man with a history of Gleason 8-9 prostate cancer dx in 2018 s/p radical prostatectomy 2018, salvage radiation early 2019, was on ADT for 1 year following that with undetectable PSAs until mid-2022 (0.3). Doubling time around 2 months I think, with local mets to a single LN. Went back on AD
I wanted to post an update about how things are going as well as info on my "lessons learned" so far. The post is long but I hope this information will help someone else. I was diagnosed with a GS 9 (4+5) on May 9th, 12/12 cores positive. Imaging (CT, bone scan and PSMA PET scan) showed lymph nod
It was exactly 1 year ago that I got my first elevated PSA test that started my prostate cancer experience (I don’t like to say “Journey”). [Details in my comic.](http://burnscomic.com) Since then, I had another PSA test (still elevated a month later), a pelvic MRI (showing pi-rads 5 areas), then a
Hi friends, Firstly thank you to everyone that responded to my original post, it was not only comforting but you shared some really good links to reference material. https://www.reddit.com/r/ProstateCancer/s/r9N5l1EXLb PET Scan Results - Unfortunately my PET scan showed that the cancer has spread in
My dad 73 was diagnosed around 2 years ago, with a gleason of 9, stage 4 and spread to his bones. He was treated with a triple therapy approach of ADT, Docetaxel and Abiraterone. 6 session of Docetaxel in 2022. His PSA started rising 3 months ago and he’s having pain in his hip. There is a lesion th
My story starts six months ago at age 52 with a biopsy after TURP surgery. The TURP was performed after I had issues with emptying my bladder and urgency. Blood tests showed a PSA of 1.16 and digital exams were normal. A urodynamics test showed my bladder was performing normally. All of the tests
Powers has some "issues" with the "price" of abiraterone: > A $10000 a month drug that nobody will have access to. Fortunately, our most excellent /u/kirbyofdeath_r has found a practical solution: > i checked on alibaba and you can outright buy the powder in the kilograms for what, $100 (or as
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
6 Reddit threads analysed for Enzalutamide
Overall Sentiment
Slightly positive
Comparison Threads
0
Avg Post Score
11 upvotes
Most discussed side effects in community
Hi everyone, I've lurked here for a while since getting my diagnosis back in July, and finally have told enough people that I feel like can start to post here for support. This all started as what looked to be a normal UTI back in April. I had some difficulty urinating and went to my GP, who confirm
Hey everyone, I just wanted to share a few things I learned while helping a loved one through prostate cancer treatment, especially around accessing affordable cancer drugs (Xtandi in my case). If you're feeling stuck because the drug your doctor recommended is insanely expensive, there are a few op
so ive been having some extreme hrt problems and my docs cant figure out whats wrong with me. I was on bica for like 2 years but it no longer works on me, taking it at even high doses seems to have no effect onme anymore. My doctor switched me to enzalutamide last week. Does anyone have any experien
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So my dad was originally diagnosed with prostate cancer in 2015. Had a prostatectomy the same year. Path showed extensive Gleson 4+5=9. He had a 4 cm extranodal extension and one of ten lymph nodes positive for disease. T3bN1N0 stage IV. He was treated with hormones for 2 years and few round of rad
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Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
Abiraterone is a CYP17 Inhibitor, while Enzalutamide belongs to the Androgen Receptor Inhibitor class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles.
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.