What is the difference between ACETAMINOPHEN AND CODEINE PHOSPHATE and OXYCODONE AND ACETAMINOPHEN?

ACETAMINOPHEN AND CODEINE PHOSPHATE and OXYCODONE AND ACETAMINOPHEN are both Opioid Analgesics, so they work through the same broad mechanism. They differ in dosing, half-life, side-effect frequency, and how individual patients tolerate them. See the head-to-head sections below for the specifics.

Is Acetaminophen and Codeine Phosphate the same as Oxycodone and Acetaminophen?

No. Acetaminophen and Codeine Phosphate (ACETAMINOPHEN AND CODEINE PHOSPHATE) and Oxycodone and Acetaminophen (OXYCODONE AND ACETAMINOPHEN) are distinct medications. They are sometimes confused because of similar branding or because they treat overlapping conditions, but they have different active ingredients and different safety profiles.

Which has fewer side effects, ACETAMINOPHEN AND CODEINE PHOSPHATE or OXYCODONE AND ACETAMINOPHEN?

Side-effect frequency varies by individual. The side-effect comparison section on this page shows FAERS-reported events for each drug side by side. FAERS is voluntary reporting, so it reflects what patients and clinicians chose to report, not absolute population risk.

Can I switch from ACETAMINOPHEN AND CODEINE PHOSPHATE to OXYCODONE AND ACETAMINOPHEN?

Switching medications should always be done under prescriber supervision. The "patient stories" section on this page includes accounts from people who have made the switch and what their transition felt like, but those are individual experiences, not protocols.

ACETAMINOPHEN AND CODEINE PHOSPHATE vs OXYCODONE AND ACETAMINOPHEN

Compare ACETAMINOPHEN AND CODEINE PHOSPHATE (Acetaminophen and Codeine Phosphate) and OXYCODONE AND ACETAMINOPHEN (Oxycodone and Acetaminophen) — clinical data, side effects, and patient experiences.

ACETAMINOPHEN AND CODEINE PHOSPHATE

Acetaminophen and Codeine Phosphate, Codeine Linctus · Opioid Analgesic

How it works

Other agent

Approved for

INDICATIONS AND USAGE Acetaminophen and codeine phosphate tablets are indicated for the management of mild to moderate pain

where treatment with an opioid is appropriate and for which alternative treatments are inadequate. Limitations of Use Because of the risks of addiction

abuse

misuse

OralTablet

OXYCODONE AND ACETAMINOPHEN

Oxycodone and Acetaminophen · Opioid Analgesic

How it works

Other agent

Approved for

INDICATIONS AND USAGE Oxycodone and Acetaminophen Tablets is indicated for the relief of moderate to moderately severe pain.

OralTablet

Quick Comparison

ACETAMINOPHEN AND CODEINE PHOSPHATEOXYCODONE AND ACETAMINOPHEN

Drug Class

Opioid Analgesic

Route

Oral

Half-Life

—

FDA Approved

—

Pregnancy

—

Side Effect Frequency Comparison

Estimated frequency (%) based on clinical trial data

Side Effects

ACETAMINOPHEN AND CODEINE PHOSPHATE

Drug Not Working

1-10%

Fatigue

1-10%

Nausea

1-10%

Headache

1-10%

Diarrhea

1-10%

Shortness of Breath

1-10%

Joint Pain

1-10%

Vomiting

0.1-1%

OXYCODONE AND ACETAMINOPHEN

Nausea

0.1-1%

Drug Not Working

0.1-1%

Fatigue

0.1-1%

Diarrhea

0.1-1%

Vomiting

0.1-1%

Anxiety

0.1-1%

Depression

0.1-1%

FDA Warnings

ACETAMINOPHEN AND CODEINE PHOSPHATE

Assess each patient’s risk prior to prescribing acetaminophen and codeine phosphate tablets and monitor all patients regularly for the development of these behaviors and conditions [see WARNINGS]
Life-Threatening Respiratory Depression Serious, life-threatening, or fatal respiratory depression may occur with use of acetaminophen and codeine phosphate tablets, especially during initiation or following a dosage increase
To reduce the risk of respiratory depression, proper dosing and titration of Acetaminophen and codeine phosphate are essential [see Warnings]
Accidental Ingestion Accidental ingestion of even one dose of Acetaminophen and codeine phosphate tablets, especially by children, can result in a fatal overdose of acetaminophen and codeine phosphate [see WARNINGS]

OXYCODONE AND ACETAMINOPHEN

WARNING Hepatotoxicity Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death

Clinical Trial Data

No head-to-head clinical studies found for ACETAMINOPHEN AND CODEINE PHOSPHATE vs OXYCODONE AND ACETAMINOPHEN.

ACETAMINOPHEN AND CODEINE PHOSPHATE vs OXYCODONE AND ACETAMINOPHEN: What You Should Know

Key Differences

Both ACETAMINOPHEN AND CODEINE PHOSPHATE and OXYCODONE AND ACETAMINOPHEN belong to the Opioid Analgesic class. While they share a similar mechanism of action, differences in pharmacokinetics, dosing, and side effect profiles may make one more suitable than the other for individual patients.

Safety Considerations

ACETAMINOPHEN AND CODEINE PHOSPHATE carries 4 FDA warnings. OXYCODONE AND ACETAMINOPHEN carries 1 FDA warning. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..

This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.

Related Comparisons

OXYCODONE AND ACETAMINOPHEN vs TRAMADOL HYDROCHLORIDE→CODEINE SULFATE vs OXYCODONE AND ACETAMINOPHEN→OXYCODONE AND ACETAMINOPHEN vs OXYCODONE HYDROCHLORIDE→BUPRENORPHINE vs OXYCODONE AND ACETAMINOPHEN→BENZHYDROCODONE AND ACETAMINOPHEN vs OXYCODONE AND ACETAMINOPHEN→BUPRENORPHINE AND NALOXONE vs OXYCODONE AND ACETAMINOPHEN→

Primary sources

Every figure on this comparison links back to its primary source. See data sources and methodology for the full provenance trail.

ACETAMINOPHEN AND CODEINE PHOSPHATE: DailyMed label · FAERS adverse events · ClinicalTrials.gov
OXYCODONE AND ACETAMINOPHEN: DailyMed label · FAERS adverse events · ClinicalTrials.gov

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ACETAMINOPHEN AND CODEINE PHOSPHATE vs OXYCODONE AND ACETAMINOPHEN

ACETAMINOPHEN AND CODEINE PHOSPHATE

Acetaminophen and Codeine Phosphate, Codeine Linctus · Opioid Analgesic

How it works

Other agent

Approved for

INDICATIONS AND USAGE Acetaminophen and codeine phosphate tablets are indicated for the management of mild to moderate pain

where treatment with an opioid is appropriate and for which alternative treatments are inadequate. Limitations of Use Because of the risks of addiction

abuse

misuse

OralTablet

OXYCODONE AND ACETAMINOPHEN

Oxycodone and Acetaminophen · Opioid Analgesic

How it works

Other agent

Approved for

INDICATIONS AND USAGE Oxycodone and Acetaminophen Tablets is indicated for the relief of moderate to moderately severe pain.

OralTablet

Quick Comparison

ACETAMINOPHEN AND CODEINE PHOSPHATEOXYCODONE AND ACETAMINOPHEN

Drug Class

Opioid Analgesic

Route

Oral

Half-Life

—

FDA Approved

—

Pregnancy

—

Side Effect Frequency Comparison

Estimated frequency (%) based on clinical trial data

Side Effects

ACETAMINOPHEN AND CODEINE PHOSPHATE

Drug Not Working

1-10%

Fatigue

1-10%

Nausea

1-10%

Headache

1-10%

Diarrhea

1-10%

Shortness of Breath

1-10%

Joint Pain

1-10%

Vomiting

0.1-1%

OXYCODONE AND ACETAMINOPHEN

Nausea

0.1-1%

Drug Not Working

0.1-1%

Fatigue

0.1-1%

Diarrhea

0.1-1%

Vomiting

0.1-1%

Anxiety

0.1-1%

Depression

0.1-1%

FDA Warnings

ACETAMINOPHEN AND CODEINE PHOSPHATE

Assess each patient’s risk prior to prescribing acetaminophen and codeine phosphate tablets and monitor all patients regularly for the development of these behaviors and conditions [see WARNINGS]
Life-Threatening Respiratory Depression Serious, life-threatening, or fatal respiratory depression may occur with use of acetaminophen and codeine phosphate tablets, especially during initiation or following a dosage increase
To reduce the risk of respiratory depression, proper dosing and titration of Acetaminophen and codeine phosphate are essential [see Warnings]
Accidental Ingestion Accidental ingestion of even one dose of Acetaminophen and codeine phosphate tablets, especially by children, can result in a fatal overdose of acetaminophen and codeine phosphate [see WARNINGS]

OXYCODONE AND ACETAMINOPHEN

WARNING Hepatotoxicity Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death

Clinical Trial Data

No head-to-head clinical studies found for ACETAMINOPHEN AND CODEINE PHOSPHATE vs OXYCODONE AND ACETAMINOPHEN.

ACETAMINOPHEN AND CODEINE PHOSPHATE vs OXYCODONE AND ACETAMINOPHEN: What You Should Know

Key Differences

Safety Considerations

This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.

Primary sources

Every figure on this comparison links back to its primary source. See data sources and methodology for the full provenance trail.

ACETAMINOPHEN AND CODEINE PHOSPHATE: DailyMed label · FAERS adverse events · ClinicalTrials.gov
OXYCODONE AND ACETAMINOPHEN: DailyMed label · FAERS adverse events · ClinicalTrials.gov