Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare AMPHETAMINE (Amphetamine) and GUANFACINE (Guanfacine) — clinical data, side effects, and patient experiences.
Amphetamine, Adderall · CNS Stimulant
How it works
12.1 Mechanism of Action Amphetamines are non-catecholamine sympathomimetic amines with CNS stimulant activity. The mode of therapeutic action in ADHD is not known. Amphetamines ar...
Approved for
Guanfacine, Intuniv, Tenex · Non-Stimulant ADHD
How it works
12.1 Mechanism of Action Guanfacine is a central alpha 2A -adrenergic receptor agonist. Guanfacine is not a central nervous system (CNS) stimulant. The mechanism of action of guanf...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 30 Reddit discussions
AMPHETAMINE
20%
positive
15 threads
GUANFACINE
47%
positive
15 threads
% of discussions mentioning each side effect
15 Reddit threads analysed for AMPHETAMINE
Overall Sentiment
Mixed
Comparison Threads
2
Avg Post Score
2,388 upvotes
Most discussed side effects in community
Threads directly comparing AMPHETAMINE to other medications
THE SAGA CONTINUES: Hi so I had my meeting with HR and the coworker I “fatshamed.” She made a comment about how she’s never seen me eat lunch and I laughed and gave a sassy clapback “yeah you should try it sometime” Here’s the post: https://www.reddit.com/r/redscarepod/comments/14nftj8/6_months_of_
So in august Dr Phil decided to talk about his disapproval of using amphetamines salts on kids, he said this pill makes people psychotic through sleep deprivation and he doesn't get why doctors give them out so easily. This is so wrong from someone who is a doctor, there is a difference between a he
My mom was telling me about the diet pills she was prescribed in the seventies. Usually she took half of one a day because she didn't have that much weight to lose and it meant only getting a prescription every other month. \*Unless\* she had a paper due. Bizarre phenomenon, a full pill taken an ho
•UPDATED BELOW • I’ve been a substance abuser my whole life. From grade school to adulthood. Uppers downers and everything in between. I’ve lied and stolen. That being said after I got clean almost 3 years ago I felt like something was off. After I talked to my sponsor to make sure I wasn’t manipula
The WSJ posted [this](https://www.wsj.com/articles/students-struggle-academically-fight-in-schools-amid-adderall-shortage-209d01e0) today and I made the mistake of reading the comments section. The article is actually not as bad as it could be, surprisingly. I've been skeptical of my own diagnosis
A lethal dose can be as low as 20 mg for a cat. And they can nab something and run off with it in the blink of an eye. You turn your back when your medications are out, you may end up standing for 10 hours in a row next to an increasingly pissed off cat in some veterinary hospital. Not an activ
Hello there this is my story (small paragraphs because u know) 1. I knew i had troubles from a while back. I’m a brilliant mind who got far in life, i’ve always had issues in executing, i was kinda oblivious to the why. 2. Symptoms got worse with total isolation, MJ, nicotine, coffee, semi bad diet
Nothing boils my blood more than getting texts saying "hurr durr I'll pay you $20 for your whole Adderall script every month" Also the one time my aunt stole my meds while I was staying at her house, then she called my (now former) psychiatrist and told him I was abusing my meds to deflect blame off
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
15 Reddit threads analysed for GUANFACINE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
751 upvotes
Most discussed side effects in community
Having ADHD fucking sucks. It’s not quirky, fun, or something that needs to become an entire personality. I’ve seen so many TikTok accounts that are all just “here’s 5 reasons you have ADHD” and then they base everything they discuss as mundane nonsense that doesn’t even pertain to ADHD. “You migh
Let me tell you a story. I’m a dad with ADHD, my oldest son has ADHD inattentive type, the middle son has ADHD hyperactive type, the baby is a baby, but we already have a sense she’s got something going on already. In the mornings, I serve up morning meds for everyone. A vyvanse for dad, fluoxetine
My son is profoundly autistic and very minimally speaking with a host of comorbidities, including ADHD combined type. We tried several stimulant formulations. He couldn't sleep. He became aggressive. He has used clonidine + guanfacine before bed to sleep. Today he started his second dose of clonidi
Decided three years ago to pursue a PhD in a discipline I love after finally took my ADHD seriously. Pursuing a doctorate was something I just didn't think I could do because of how my brain handles unstructured tasks (like writing a dissertation). Turns out with the right drugs (guanfacine + wellbu
I haven’t been able to sit down and read literally just a CHAPTER of a book in like 6 years. I crave just…. Sitting down and focusing on one task. Reading a book. Doing a puzzle. Cleaning my room. For reference I am diagnosed with adhd-c and on Sertraline and Guanfacine. I been on both for like?
I can’t believe nobody has ever recommended this drug to me before. I always struggled with stimulants as there would be days where I would have breakdowns or hyper focus on the wrong thing, couldn’t sleep.. etc. I’ve been taking guanfacine and bupropion for about a month and I REALLY NOTICE a diffe
Maybe it’s just me but I’ve gone through a gauntlet of medications (Adderall, Focalin XR, Ritalin, Metadate, Vyvanse, Dexedrine, Concerta, Wellbutrin, Strattera, Guanfacine) and each time I’ve ended up disappointed in them. At best, they give me a bit of energy/wakefulness and make it slightly easie
This is really long. I’m tired and frustrated, sorry. So I just got off my 11p-7a in the emergency department. We have this one doc, LC, who I’m pretty sure is out to get me. Does this sound dramatic? Yes. Do I actually think it’s true? I’ve been trying to convince myself I’m crazy, but I actually
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
AMPHETAMINE is a CNS Stimulant, while GUANFACINE belongs to the Non-Stimulant ADHD class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles.
AMPHETAMINE carries 4 FDA warnings. GUANFACINE carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.