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Compare AZATHIOPRINE (Azathioprine) and METHOTREXATE (METHOTREXATE) — clinical data, side effects, and patient experiences.
Azathioprine · Immunosuppressant
How it works
Other agent
Approved for
METHOTREXATE, Trexall, Otrexup · DMARD
How it works
12.1 Mechanism of Action Methotrexate inhibits dihydrofolic acid reductase. Dihydrofolates must be reduced to tetrahydrofolates by this enzyme before they can be utilized as carrie...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 24 Reddit discussions
AZATHIOPRINE
33%
positive
9 threads
METHOTREXATE
20%
positive
15 threads
% of discussions mentioning each side effect
9 Reddit threads analysed for AZATHIOPRINE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
27 upvotes
Most discussed side effects in community
My dad (73M) was rushed to the hospital last Thursday with severe chest/back pain. Over the course of a day, his troponin level went from 270, to 5,000, to 139,000, indicating that he was, in fact, having a heart attack. They did a heart cath and discovered blockage in a vessel. This would be pretty
I (14 F) got diagnosed with autoimmune hepatitis in October 2023 when I was 13. I also had my gallbladder removed on march 2023 because the doctors had found stones in them. Ever since 2018 I've been complaining about pain and nausea after eating or drinking anything. My mum took me to many doctors
35 X (AGAB F). Possibly pertinent health info: lupus & immune suppressed (not sure if important, but just in case it might affect this, there's something else going on where labs show normal C3 but low C4, low WBC, and low % counts; rheumatologist doesn’t think it’s from my azathioprine and so I
I know this seems a tad bit silly but I'd appreciate you taking 2 min of your time to answer this, mainly to calm her down. My (17M, not that it matters in this case) mother dearest is more of the panicky helicopter parent type. I'm buying myself a new PC and am planning on having it on my desk next
I'm 21F, 5'8", around 130lbs. Physical conditions: Crohn's, cholinergic urticaria, asthma, possible psoriasis. Medications for physical ailments are Humira, azathioprine, topical creams, and an inhaler. This has been going on for over four months now. It's a terrible pain in a star shape with the ce
I wondered if anyone has some insight into what’s going on with my body? I’m a 32 y/o F. I have been lactating a little from one breast only. ( I used to be on Amisulpride and had ridiculously high prolactin levels (over 1000) so I was put on Aripiprazole to help try and bring the levels down which
F(41), 5’8”, 155 lbs, non-smoker, Crohn’s disease with extra intestinal manifestations, current flare 3 months, w/ Gi symptoms, bleeding gums, arthritis, HS, vaginal inflammation meds: Entyvio, Cimzia, Azathioprine(just restarted) w/ allopurinol, Bactrim I have Crohn’s disease and have found the C
Hi guys, I’ll start by saying that I’ve read maybe too much, making me lean to talk here. Here is a small bio of pre-diagnostic: I’m a 28 y.o. very active young white male. 6 feet tall. Weed smoker, no alcool at all. I’ve lost about 50 pounds in two years, now 185lb (after a breakup, took my healt
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
15 Reddit threads analysed for METHOTREXATE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
125 upvotes
Most discussed side effects in community
Edit #3: I passed out today on my apartment steps out of absolutely the worst pain I’ve ever had in my life and someone saw me and called an ambulance. I finally got a diagnosis in the emergency room after bawling my eyes out of frustration at this entire situation and they found out I have a corona
This is going to be so, so, so long and I’m so sorry. But we don’t know what else to do. I’ve tried to compress it the best I could. 3f with medical mystery. First year of life: -couldn’t latch until 2 months old -refused all food, in all forms. -up every 20 minutes every single night, wouldn’t
Hey /r/pharmacy I'm a mod over on the /r/lupus sub and we got our [first report](https://www.reddit.com/r/lupus/comments/vt9owi/denied_my_methotrexate/) from a from an established user of the sub saying their methotrexate prescription has been denied due to the recent overturning of roe. This has [b
I've been dancing my heart out for the last couple days. In public. I don't know why I'm just happy to be alive and moving and I don't even need music. It is honestly so abnormal for me to be dancing that I figured I should ask here? Nothing bad comes from the urge to dance in public yeah? F19 5'4 1
https://www.oscn.net/dockets/GetCaseInformation.aspx?db=oklahoma&number=CF-2023-2233&cmid=4194257 Maybe fuzzy on details, but basically this case was a doc who ordered mtx for a patient and sent the order as qd vs qw. Pharmacist filled it. Patient died. Obviously very sad, we just normally
F23 just ran a 10k. For reference I use to be a big runner so I have pride but haven't ran in a few months so no foundation. Absolutely killed myself to PR today. The race was brutal with cramping in my legs and lower back. I have probably ran hundreds of races. NEVER before have I gotten so immedi
25F USA 130 lbs 5'6 Meds: Prednisone, Cymbalta, 5mg Percocet 3x a day I will appreciate any insight. I'm so frustrated and exhausted I can hardly think straight by this point. Typing this from a hospital bed, actually! I will try to provide how this affects me both physically and mentally, and my st
Be careful and vigilant when dealing with maverick prescribers. Look at this example, the dosage was flagged and followed up on yet dispensed regardless. https://www.theage.com.au/national/victoria/drug-for-common-skin-disorder-implicated-in-grandfather-s-death-20180206-p4yzik.html
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
AZATHIOPRINE is a Immunosuppressant, while METHOTREXATE belongs to the DMARD class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles.
AZATHIOPRINE carries 4 FDA warnings. METHOTREXATE carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.