Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare BUPROPION (bupropion) and Levomilnacipran (Fetzima) — clinical data, side effects, and patient experiences.
bupropion, Wellbutrin, Zyban · Atypical Antidepressant (NDRI)
How it works
12.1 Mechanism of Action The mechanism of action of bupropion is unknown, as is the case with other antidepressants. However, it is presumed that this action is mediated by noradre...
Approved for
Fetzima · SNRI
How it works
SNRI with preferential norepinephrine reuptake inhibition over serotonin, providing antidepressant and functional improvement effects.
Approved for
Estimated frequency (%) based on clinical trial data
No specific warnings
Based on 19 Reddit discussions
BUPROPION
54%
positive
13 threads
Levomilnacipran
50%
positive
6 threads
% of discussions mentioning each side effect
13 Reddit threads analysed for BUPROPION
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
69 upvotes
Most discussed side effects in community
As I get older, I’m starting to become more aware of the telltale signs that my depression symptoms are getting worse. I’ve noticed that one very specific symptom is that I feel nostalgic about so many things. In a melancholy way, not a fun way. I think it’s my brain’s way of trying to comfort me by
I obviously am not cured but it’s easily my favorite one I’ve been on. I want to know if y’all have ever started a med and were just blown away!! For me, it’s Bupropion (Wellbutrin XL). It helped reduce my depression smoking and my lack of motivation. I’ve genuinely never been happier. ETA: It’s bee
I have been a reader of this sub-reddit for some time now, but it is time for me to post. I am a first generation Asian-American and I have severe depression. I am taking bupropion sr1 at 50mg. The meds work for the most part to the extent that I can function, but at times I feel a huge surge of
So as the title suggests, ive recently come out of a huge stent of depression, about 10 years worth. Because of how long ive been depressed, most of my entire personality was taken over by it. I became withddrawn, self defeating, gave up my activities and hobbies years ago because they were no long
I have been so exhausted lately that I am on the verge of dizziness some days. I get about eight hours of sleep, so I should be well rested enough, but I wake up barely able to get out of bed. It's also really cold right now, which is sapping a lot of what little energy I have left. I am trying not
After four years on a low dose of bupropion XL (100 mg) , I decided to stop taking it. My pharmacist told me to taper off slowly, so for the first 2.5 weeks I took it every 2nd day, and for the next 2.5 weeks I took it every 3rd day. The tapering process went smoothly, so I figured it was safe to st
I’ve been depressed and anxious since I was 10 (turning 22 this year..) and it almost feels like every year, I just lose a piece of myself. Every year, I lose more energy and more hope. I struggle with so much self doubt and self hatred. I wouldn’t kill myself but I often think of how great it would
I'm only 4 foot 10, and gained about 15 pounds in 4 months on mirtazapine. That is something like the equivalent of 6 or 8 dress sizes. I need to stay on the drug because of the severity of my depression and sleep dysfunction, with long covid. Over the course of 2 months I've lost 9 of those pounds,
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
6 Reddit threads analysed for Levomilnacipran
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
14 upvotes
Most discussed side effects in community
I took a Genetic Test called Genesight and it listed the following medicines to use as directed (highlighted in green) but I don't think any of them are for OCD. Does anyone have experience taking any of these medicines specifically for OCD? * bupropion (Wellbutrin®) * desipramine (Norpramin®) * des
I wanted to share my experience with Viibryd thus far, since when I first starting looking into it after being prescribed it, I mostly found people saying how they had a bad time on it. Quick background, this is the 6th antidepressant I've tried. Before Viibryd, I was on citalopram for 8 years and
**Most Common Antidepressants** * *SSRI's* \- Works on Serotonin * Sertraline (Zoloft) * Fluoxetine (Prozac) * Paroxetine (Paxil) * Citalopram (Celexa) * Escitalopram (Lexapro) * Fluvoxamine (Luvox) * Trazodone (Desyrel) * Vilazodone (Viibryd) * Vortioxetine (Trintellix)
I'm really struggling with my depression post-surgery. I think a big part of the problem may be my anti-depressant. I have had great success with Fetzima/levomilnacipran, a little-used antidepressant that unfortunately, ONLY comes in an extended release version. I think that, with my rny and shorte
Apologies for the wall of text - I've done my best to condense 15 years of crap into a reasonably sized post. ​ I have a depressive disorder. This much is obvious. I've been on antidepressants for 15 years. I've tried 6 of them in total (fluoxetine, sertraline, trazodone, bupropion, vilaz
Hello, I'm am getting off Wellbutrin, and want to research an alternative drug to ask my DOC about. This is for MDD, and this is what I found: Lexapro - escitalopram (SSRI, seems fine, side effects don't sound good.) Venlafaxine-Effexor (SNRI, similar to Wellbutrin, standard SNRI side effects)) Dul
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
BUPROPION is a Atypical Antidepressant (NDRI), while Levomilnacipran belongs to the SNRI class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles.
BUPROPION carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.