CHLORTHALIDONE vs RAMIPRIL

Compare CHLORTHALIDONE (Chlorthalidone) and RAMIPRIL (Ramipril) — clinical data, side effects, and patient experiences.

CHLORTHALIDONE

Chlorthalidone · Thiazide Diuretic

How it works

Thiazide Diuretic agent

Approved for

hepatic cirrhosis

and corticosteroid and estrogen therapy. Chlorthalidone has also been found useful in edema due to various forms of renal dysfunction

such as nephrotic syndrome

acute glomerulonephritis

OralTablet

RAMIPRIL

Ramipril, Altace, Tritace · ACE Inhibitor

How it works

12.1 Mechanism of Action Ramipril and ramiprilat inhibit ACE in human subjects and animals. Angiotensin converting enzyme is a peptidyl dipeptidase that catalyzes the conversion of...

Approved for

See full prescribing information

OralTablet

Quick Comparison

CHLORTHALIDONERAMIPRIL

Drug Class

Thiazide Diuretic

ACE Inhibitor

Route

Oral

Half-Life

—

FDA Approved

—

Pregnancy

Side Effect Frequency Comparison

Estimated frequency (%) based on clinical trial data

Side Effects

CHLORTHALIDONE

Drug Not Working

>10%

Nausea

>10%

Fatigue

1-10%

Diarrhea

1-10%

Dizziness

1-10%

Headache

1-10%

Shortness of Breath

1-10%

Weakness

0.1-1%

RAMIPRIL

Shortness of Breath

1-10%

Fatigue

1-10%

Nausea

1-10%

Diarrhea

1-10%

Dizziness

1-10%

Drug Not Working

1-10%

Vomiting

1-10%

Headache

1-10%

FDA Warnings

CHLORTHALIDONE

WARNINGS Chlorthalidone should be used with caution in severe renal disease

RAMIPRIL

WARNINGS AND PRECAUTIONS ACE inhibitor use has been associated with the following: • Angioedema, with increased risk in patients with a prior history ( 5
3 ) • Increased risk of renal impairment when combined with another blocker of the renin-angiotensin-aldosterone system ( 5
, ACE inhibitors) affect the metabolism of eicosanoids and polypeptides, including endogenous bradykinin, patients receiving these drugs (including ramipril) may be subject to a variety of adverse reactions, some of them serious
Angioedema Head and Neck Angioedema: Patients with a history of angioedema unrelated to ACE inhibitor therapy may be at increased risk of angioedema while receiving an ACE inhibitor

Community Sentiment Analysis

Based on 15 Reddit discussions

CHLORTHALIDONE

27%

positive

15 threads

RAMIPRIL

positive

0 threads

Community-Reported Side Effects

% of discussions mentioning each side effect

Community Discussions

15 Reddit threads analysed for CHLORTHALIDONE

Overall Sentiment

Mixed

Comparison Threads

Avg Post Score

11 upvotes

Most discussed side effects in community

Anxiety (3)

Fatigue (2)

Dizziness (2)

Edema (1)

Itching (1)

Diarrhea (1)

Patient Experiences (r/pharmacy, r/AskDocs & more)

Chlorthalidone and HCTZ, what am I missing?

I start by saying I'm an NP student, not a pharmacist. In my clinical rotations the providers I am under are all prescribing HCTZ with no good explanation why. In my acute inpatient job, everyone is on HCTZ. I can't even think of one time I have ever had one of my patients come in on Chlorthalidone

r/pharmacy63498y ago

Knee replacement surgery, no blood thinners ordered, patient died 10 days later of multiple blood clots in both lungs. D…

My mother in law had a knee replacement surgery and was doing well. She was mobile and doing PT. 10 days post op she collapsed and was gone before she hit the ground, they ruled it a pulmonary embolism. I just reviewed the detailed autopsy. She had multiple clots in all lobes of both lungs. "The

r/AskDocs37219y ago

This Atenolol shortage though... (X-post from /r/talesfromthepharmacy)

I've been working the past couple of days and never before realized how many patients we have on Atenolol (+ or - Chlorthalidone....). I know we are all suffering the brunt of this shortage. My question is, now that we are in such a shortage, any recommendations on how to take the edge off of the At

r/pharmacy1798y ago

Pharmacology

Guys while chlorthalidone is more potent than hydrochlorothiazide at lower doses why combinations of ACE-I + hydrochlorothiazide are more common than chlorthalidone

r/pharmacy11141y ago

Why have classic drugs like prindapril, indapamide, and chlorthalidone used in major trials (ALLHAT, PROGRESS) aren't us…

As the title asks. We see more lisinopril for the ACE-Is, HCTZ for the thiazide diuretics, etc...

r/pharmacy61512y ago

Why do we rest before taking our BP? Is that a false sense of “normal”?

I (43 yr, female, taking 10mg chlorthalidone daily) have begun monitoring my BP at home and am curious why they say to sit still for five minutes. I’m almost always up and about and can’t think of many times during the day I’d really be still. Are the guidelines set up in such a way that we only con

r/AskDocs595y ago

Compounded chlorthalidone liquid?

Hey, I'm an amb care pharmacist which means I've got compounding amnesia. We have a guy who really needs a lower dose of chlorthalidone than we can get by cutting a 25mg tab. Does anyone have a recipe for compounded liquid, or good refs to search for this? I swear 10 years ago of have known this.

r/pharmacy465y ago

Unexplained fatigue and swelling in legs along with low sodium levels

My father (75M) is 5'8", 150 lbs, Caucasian and is experiencing unexplained fatigue and swelling in his legs. We are located in Canada. He is currently taking Metoprolol (25 mg), Atorvastatin (10 mg) and Ramipril (1.25 mg). He drinks one or two beers a week. He was a smoker for about 10 years in hi

r/AskDocs4143y ago

Fatigue

Edema

Itching

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

Community Discussions

No community discussions found for RAMIPRIL yet.