Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare CLONIDINE (Clonidine) and GUANFACINE (Guanfacine) — clinical data, side effects, and patient experiences.
Clonidine · Non-Stimulant ADHD
How it works
Other agent
Approved for
Guanfacine, Intuniv, Tenex · Non-Stimulant ADHD
How it works
12.1 Mechanism of Action Guanfacine is a central alpha 2A -adrenergic receptor agonist. Guanfacine is not a central nervous system (CNS) stimulant. The mechanism of action of guanf...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 29 Reddit discussions
CLONIDINE
14%
positive
14 threads
GUANFACINE
47%
positive
15 threads
% of discussions mentioning each side effect
14 Reddit threads analysed for CLONIDINE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
191 upvotes
Most discussed side effects in community
Height: 5’10” Weight: 200lbs American White Male Past Medical History: Concussion/GERD/Appendectomy. I was a Paramedic for 3 years during the COVID Pandemic. One day, I finally caught COVID from Christ knows where. Immediately after .. I was having episodes of lightheadedness and tachycardia. One
Below is a summary of my daughter’s past ten days. Our doctors are stumped. Any ideas or suggestions are greatly appreciated. Summary of Past 10 Days – 14-Year-Old Girl Baseline • Previously healthy, no major medical or psychiatric history reported, no drug use, no family history of mental illness,
My father (79 male) has stopped caring for himself. He has ocd, bpd, type 2 diabetes and struggles with depression and pretty severe anxiety. I'm not sure of his dosages, but he is prescribed welbutrin, metformin, valium, and clonidine periodically steals and abuses my brother's aderall and abuses a
19FtM, 5’4, 241lbs, white, USA, 200mg Geodon, 60mg Cymbalta, 0.2mg clonidine, 1200mg gabapentin, 15mg mirtazipine, 300mg lithium, daily testosterone topical gel, Kyleena IUD, 1000mg of Diamox. So I have chronic insomnia. I’m on the mirtazipine and the clonidine for it. For some reason, I became comp
32yr old female. 140lbs, 5’1”. History of anxiety and depression. I was inpatient in 2015 for suicide attempt. I stopped taking my meds when I found out I was pregnant in 2016. It’s weird, around 6/7th month of pregnancy I felt better and after birth I didn’t need meds. I felt better. I had a marita
One of my patient's is using clonidine to help with methadone withdrawal, didn't know that. I want to try and make this a weekly/semi-weekly thing to increase interest in this subreddit. Any thoughts?
Working in poison control, children getting into clonidine is not uncommon. It's sometimes around grandma's house or an older sibling has a Rx for ADHD. Usually the kid is drowsy for several hours or some bradycardia develops, but I've fortunately not had to deal with too many cases requiring intuba
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
15 Reddit threads analysed for GUANFACINE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
751 upvotes
Most discussed side effects in community
Having ADHD fucking sucks. It’s not quirky, fun, or something that needs to become an entire personality. I’ve seen so many TikTok accounts that are all just “here’s 5 reasons you have ADHD” and then they base everything they discuss as mundane nonsense that doesn’t even pertain to ADHD. “You migh
Let me tell you a story. I’m a dad with ADHD, my oldest son has ADHD inattentive type, the middle son has ADHD hyperactive type, the baby is a baby, but we already have a sense she’s got something going on already. In the mornings, I serve up morning meds for everyone. A vyvanse for dad, fluoxetine
My son is profoundly autistic and very minimally speaking with a host of comorbidities, including ADHD combined type. We tried several stimulant formulations. He couldn't sleep. He became aggressive. He has used clonidine + guanfacine before bed to sleep. Today he started his second dose of clonidi
Decided three years ago to pursue a PhD in a discipline I love after finally took my ADHD seriously. Pursuing a doctorate was something I just didn't think I could do because of how my brain handles unstructured tasks (like writing a dissertation). Turns out with the right drugs (guanfacine + wellbu
I haven’t been able to sit down and read literally just a CHAPTER of a book in like 6 years. I crave just…. Sitting down and focusing on one task. Reading a book. Doing a puzzle. Cleaning my room. For reference I am diagnosed with adhd-c and on Sertraline and Guanfacine. I been on both for like?
I can’t believe nobody has ever recommended this drug to me before. I always struggled with stimulants as there would be days where I would have breakdowns or hyper focus on the wrong thing, couldn’t sleep.. etc. I’ve been taking guanfacine and bupropion for about a month and I REALLY NOTICE a diffe
Maybe it’s just me but I’ve gone through a gauntlet of medications (Adderall, Focalin XR, Ritalin, Metadate, Vyvanse, Dexedrine, Concerta, Wellbutrin, Strattera, Guanfacine) and each time I’ve ended up disappointed in them. At best, they give me a bit of energy/wakefulness and make it slightly easie
This is really long. I’m tired and frustrated, sorry. So I just got off my 11p-7a in the emergency department. We have this one doc, LC, who I’m pretty sure is out to get me. Does this sound dramatic? Yes. Do I actually think it’s true? I’ve been trying to convince myself I’m crazy, but I actually
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
Both CLONIDINE and GUANFACINE belong to the Non-Stimulant ADHD class. While they share a similar mechanism of action, differences in pharmacokinetics, dosing, and side effect profiles may make one more suitable than the other for individual patients.
CLONIDINE carries 3 FDA warnings. GUANFACINE carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.