Compare DESVENLAFAXINE (Desvenlafaxine) and PAROXETINE (Paroxetine) — clinical data, side effects, and patient experiences.
Desvenlafaxine, Pristiq · SNRI
How it works
12.1 Mechanism of Action The exact mechanism of the antidepressant action of desvenlafaxine is unknown, but is thought to be related to the potentiation of serotonin and norepineph...
Approved for
Paroxetine, Paxil · SSRI
How it works
12.1 Mechanism of Action The mechanism of action of paroxetine in the treatment of MDD, SAD, OCD, PD, GAD, and PTSD is unknown, but is presumed to be linked to potentiation of sero...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 26 Reddit discussions
DESVENLAFAXINE
21%
positive
14 threads
PAROXETINE
17%
positive
12 threads
% of discussions mentioning each side effect
14 Reddit threads analysed for DESVENLAFAXINE
Overall Sentiment
Mixed
Comparison Threads
1
Avg Post Score
143 upvotes
Most discussed side effects in community
Threads directly comparing DESVENLAFAXINE to other medications
I’ve been doing some reading about the 2 available forms of desvenlafaxine, but I think I’ve confused myself at this point. Other than the salt form, is there any major difference between the two? When looking at FDA orange book online, Desvenlafaxine ER succinate has an AB rating to Desvenlafaxine
I have been dealing with mysterious tachycardia and heart palpitations for almost a decade. I have no genetic or lifestyle flags for heart issues, and basically have just been told I should try more cardio and cut out the caffeine. For reference, my usual resting heart rate hangs around 95-105bpm. T
EDIT: Thank you so much to everyone who replied to this post I really appreciate all the inputs, you guys are seriously more helpful then some doctors I have seen. I've got a lot more to think about in terms of what my issues could be caused by including POTS which I think is a real possibility, ADH
I'm a [20M] 6'3 238 lbs I dont smoke tobacco, I do smoke pot, I'm on desvenlafaxine and. Amitriptyline. and an hour ago I accidentally inhaled my water bottle cap, it went down my throat easily and now an hour and a half later I'm gassy and bloated and feel overall icky, should I go to the ER? Shou
I cannot find anything about mechanism pointing towards the uniqueness of duloxetine over venlafaxine or desvenlafaxine.
Subject of post (my gf- she is too anxious about this to post for herself) is 38 female, 5'2, 240lbs approx, takes methimazol, famotidine, adderall, desvenlafaxine, vit d. Just got off seroquel that she had been on for years. She suffers from MS, adhd, major depression, asthma, bipolar 1, and season
About a month ago I (19F) was prescribed Buspirone for anxiety and Desvenlafaxine for depression. These medications were chosen after I took a Genesight test and the results showed them to be among the best options. The person that prescribed them was not my usual consultant, but was the person I wa
I am a pharmacy technician with over 20 years of experience across just about every faction of pharmacy besides Big Pharma/R&D. I currently have a full time job in RX finance, and an evening gig in LTC data entry. The other day at my part time shop, I literally happened upon a script by chance
I (29F) learned in another Reddit thread that Miralax is derived from polyethylene glycol, a petroleum-based compound, derived from petroleum byproducts. This information obviously freaks me out. All of my medications have constipation/hard bowel movements as a side effect (Desvenlafaxine, clonidin
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
12 Reddit threads analysed for PAROXETINE
Overall Sentiment
Slightly negative
Comparison Threads
0
Avg Post Score
33 upvotes
Most discussed side effects in community
Yes, some individuals will be on them for life, not have issues and good success on them. Some will struggle hard and not be able to get off of them or find one that works well for them. Some will get their bodies destroyed and have the hardest fight of their life to get off these medications. I am
I've read so many sad/bad stories about Paxil/Paroxetine while I was still on it, that I decided I'll write my own once I'm off meds, so that people who are afraid of Paxil after reading all the spooks and scares, would see success stories too. I had major panic attacks and severe anxiety. Anxiety h
How come a psychiatrist prescribes an antidepressant and tells the patient to not look at the side effects? He also assured that there were no effects on sexual function despite the fact that paroxetine is used to treat premature ejaculation in several studies. After deciding to stop paroxetine (due
I just saw a post on instagram and people were saying that brain zaps were genuinely the worst experience of their life, and someone even went to the ER because of it. I’m on day 3 of Paroxetine and I don’t even want to continue (obviously know I can’t just quit now) because of these side effects. I
Hey, looking for a place to vent a little and maybe get some validation. I'm so, so mad and now even more scared as it seems I'm getting no medical help on this. I've stopped Paxil around Christmas. Obviously, I started getting all the fun side effects such as insomnia, nausea and most of all the br
This may seem crazy. But when i was 20ish i was prescribed Deroxat (Paroxetine) for mild depression an social anxiety It worked right from day one, i was numb as wood, that sounds odd but for the first time i didn't have negative feeling (nor good) and that was sooo fucking relaxing, not worrying a
Hi Reddit! I just wanted to say that hope is out there. I'm using a throw-away for obvious reasons. Here is my story. ---------------------------------------------------------------------------------------------------------------------------------------------- I had been sinking into depression wors
Hello everybody, I hope all of you are doing okay. So I went on a trip 5 days ago, while everything was on point, I forgot the most important thing to bring with me, I thought it was already in the luggage so I have not bothered checking twice. I take Paroxetine 40mg, and the withdrawals are mild, n
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
DESVENLAFAXINE is a SNRI, while PAROXETINE belongs to the SSRI class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles.
Both medications are approved for See full prescribing information. When two drugs treat the same condition, the choice between them often depends on the patient's medical history, other medications, tolerability, and prescriber preference.
DESVENLAFAXINE carries 4 FDA warnings. PAROXETINE carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.
Every figure on this comparison links back to its primary source. See data sources and methodology for the full provenance trail.