Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare DEXTROAMPHETAMINE (XELSTRYM) and GUANFACINE (Guanfacine) — clinical data, side effects, and patient experiences.
XELSTRYM · CNS Stimulant
How it works
12.1 Mechanism of Action Amphetamines are non-catecholamine sympathomimetic amines with CNS stimulant activity. The exact mode of therapeutic action in ADHD is not known.
Approved for
Guanfacine, Intuniv, Tenex · Non-Stimulant ADHD
How it works
12.1 Mechanism of Action Guanfacine is a central alpha 2A -adrenergic receptor agonist. Guanfacine is not a central nervous system (CNS) stimulant. The mechanism of action of guanf...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 19 Reddit discussions
DEXTROAMPHETAMINE
0%
positive
4 threads
GUANFACINE
47%
positive
15 threads
% of discussions mentioning each side effect
4 Reddit threads analysed for DEXTROAMPHETAMINE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
88 upvotes
So most stimulants like Amphetamine and Dextroamphetamine are spelled with a “ph” instead of an “f” like Lisdexamfetamine. Does anyone know why that is? Just thought it was interesting
My parents are worried that my coworkers will view me differently if I drop my own prescriptions off at my own pharmacy. How common is it for employees to get their own drugs, especially schedules substances filled at their own pharmacy. Also, would it be strange to request a certain manufacturer fo
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
15 Reddit threads analysed for GUANFACINE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
751 upvotes
Most discussed side effects in community
Having ADHD fucking sucks. It’s not quirky, fun, or something that needs to become an entire personality. I’ve seen so many TikTok accounts that are all just “here’s 5 reasons you have ADHD” and then they base everything they discuss as mundane nonsense that doesn’t even pertain to ADHD. “You migh
Let me tell you a story. I’m a dad with ADHD, my oldest son has ADHD inattentive type, the middle son has ADHD hyperactive type, the baby is a baby, but we already have a sense she’s got something going on already. In the mornings, I serve up morning meds for everyone. A vyvanse for dad, fluoxetine
My son is profoundly autistic and very minimally speaking with a host of comorbidities, including ADHD combined type. We tried several stimulant formulations. He couldn't sleep. He became aggressive. He has used clonidine + guanfacine before bed to sleep. Today he started his second dose of clonidi
Decided three years ago to pursue a PhD in a discipline I love after finally took my ADHD seriously. Pursuing a doctorate was something I just didn't think I could do because of how my brain handles unstructured tasks (like writing a dissertation). Turns out with the right drugs (guanfacine + wellbu
I haven’t been able to sit down and read literally just a CHAPTER of a book in like 6 years. I crave just…. Sitting down and focusing on one task. Reading a book. Doing a puzzle. Cleaning my room. For reference I am diagnosed with adhd-c and on Sertraline and Guanfacine. I been on both for like?
I can’t believe nobody has ever recommended this drug to me before. I always struggled with stimulants as there would be days where I would have breakdowns or hyper focus on the wrong thing, couldn’t sleep.. etc. I’ve been taking guanfacine and bupropion for about a month and I REALLY NOTICE a diffe
Maybe it’s just me but I’ve gone through a gauntlet of medications (Adderall, Focalin XR, Ritalin, Metadate, Vyvanse, Dexedrine, Concerta, Wellbutrin, Strattera, Guanfacine) and each time I’ve ended up disappointed in them. At best, they give me a bit of energy/wakefulness and make it slightly easie
This is really long. I’m tired and frustrated, sorry. So I just got off my 11p-7a in the emergency department. We have this one doc, LC, who I’m pretty sure is out to get me. Does this sound dramatic? Yes. Do I actually think it’s true? I’ve been trying to convince myself I’m crazy, but I actually
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
DEXTROAMPHETAMINE is a CNS Stimulant, while GUANFACINE belongs to the Non-Stimulant ADHD class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles. DEXTROAMPHETAMINE is administered via Transdermal, whereas GUANFACINE uses Oral. Route of administration can affect onset of action and patient adherence.
DEXTROAMPHETAMINE carries 4 FDA warnings. GUANFACINE carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.