DIMETHYL FUMARATE vs TERIFLUNOMIDE

Compare DIMETHYL FUMARATE (Dimethyl Fumarate) and TERIFLUNOMIDE (Teriflunomide) — clinical data, side effects, and patient experiences.

DIMETHYL FUMARATE

Dimethyl Fumarate, Tecfidera · Other

How it works

12.1 Mechanism of Action The mechanism by which dimethyl fumarate (DMF) exerts its therapeutic effect in multiple sclerosis is unknown. DMF and the metabolite, monomethyl fumarate ...

Approved for

1 INDICATIONS AND USAGE Dimethyl fumarate delayed-release capsules are indicated for the treatment of relapsing forms of multiple sclerosis (MS)

to include clinically isolated syndrome

relapsing-remitting disease

and active secondary progressive disease

OralTablet

TERIFLUNOMIDE

Teriflunomide, Aubagio · DMARD

How it works

12.1 Mechanism of Action Teriflunomide, an immunomodulatory agent with anti-inflammatory properties, inhibits dihydroorotate dehydrogenase, a mitochondrial enzyme involved in de no...

Approved for

1 INDICATIONS AND USAGE Teriflunomide tablets are indicated for the treatment of relapsing forms of multiple sclerosis (MS)

to include clinically isolated syndrome

relapsing-remitting disease

and active secondary progressive disease

OralTablet

Quick Comparison

DIMETHYL FUMARATETERIFLUNOMIDE

Drug Class

Other

DMARD

Route

Oral

Half-Life

—

FDA Approved

—

Side Effect Frequency Comparison

Estimated frequency (%) based on clinical trial data

Side Effects

DIMETHYL FUMARATE

Nausea

1-10%

Diarrhea

1-10%

Fatigue

1-10%

Vomiting

1-10%

Drug Not Working

1-10%

Headache

0.1-1%

Itching

0.1-1%

Falls

0.1-1%

TERIFLUNOMIDE

Hair Loss

>10%

Fatigue

1-10%

Diarrhea

1-10%

Falls

1-10%

Headache

1-10%

Drug Not Working

1-10%

Tingling/Numbness

1-10%

Nausea

1-10%

FDA Warnings

DIMETHYL FUMARATE

5 WARNINGS AND PRECAUTIONS Anaphylaxis and angioedema: Discontinue and do not restart dimethyl fumarate if these occur
2 ) Herpes zoster and other serious opportunistic infections: Consider withholding dimethyl fumarate in cases of serious infection until the infection has resolved
PML is an opportunistic viral infection of the brain caused by the JC virus (JCV) that typically only occurs in patients who are immunocompromised, and that usually leads to death or severe disability
A fatal case of PML occurred in a patient who received dimethyl fumarate for 4 years while enrolled in a clinical trial

TERIFLUNOMIDE

5 WARNINGS AND PRECAUTIONS • Elimination of teriflunomide tablets can be accelerated by administration of cholestyramine or activated charcoal for 11 days
Consider suspending treatment with teriflunomide tablets in case of serious infection
Patients with pre-existing liver disease and patients taking other hepatotoxic drugs may be at increased risk for developing liver injury when taking teriflunomide tablets
Teriflunomide tablets are contraindicated in patients with severe hepatic impairment [see Contraindications (4) ]

Clinical Trial Data

No head-to-head clinical studies found for DIMETHYL FUMARATE vs TERIFLUNOMIDE.

DIMETHYL FUMARATE vs TERIFLUNOMIDE: What You Should Know

Key Differences

DIMETHYL FUMARATE is a Other, while TERIFLUNOMIDE belongs to the DMARD class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles.

Shared Indications

Both medications are approved for to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, to include clinically isolated syndrome. When two drugs treat the same condition, the choice between them often depends on the patient's medical history, other medications, tolerability, and prescriber preference.

Safety Considerations

DIMETHYL FUMARATE carries 4 FDA warnings. TERIFLUNOMIDE carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..

This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.

Related Comparisons

LEFLUNOMIDE vs TERIFLUNOMIDE→HYDROXYCHLOROQUINE SULFATE vs TERIFLUNOMIDE→METHOTREXATE vs TERIFLUNOMIDE→Hydroxychloroquine vs TERIFLUNOMIDE→DIMETHYL FUMARATE vs FINGOLIMOD→DIMETHYL FUMARATE vs GLATIRAMER→

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DIMETHYL FUMARATE vs TERIFLUNOMIDE

Compare DIMETHYL FUMARATE (Dimethyl Fumarate) and TERIFLUNOMIDE (Teriflunomide) — clinical data, side effects, and patient experiences.

DIMETHYL FUMARATE

Dimethyl Fumarate, Tecfidera · Other

How it works

12.1 Mechanism of Action The mechanism by which dimethyl fumarate (DMF) exerts its therapeutic effect in multiple sclerosis is unknown. DMF and the metabolite, monomethyl fumarate ...

Approved for

1 INDICATIONS AND USAGE Dimethyl fumarate delayed-release capsules are indicated for the treatment of relapsing forms of multiple sclerosis (MS)

to include clinically isolated syndrome

relapsing-remitting disease

and active secondary progressive disease

OralTablet

TERIFLUNOMIDE

Teriflunomide, Aubagio · DMARD

How it works

12.1 Mechanism of Action Teriflunomide, an immunomodulatory agent with anti-inflammatory properties, inhibits dihydroorotate dehydrogenase, a mitochondrial enzyme involved in de no...

Approved for

1 INDICATIONS AND USAGE Teriflunomide tablets are indicated for the treatment of relapsing forms of multiple sclerosis (MS)

to include clinically isolated syndrome

relapsing-remitting disease

and active secondary progressive disease

OralTablet

Quick Comparison

DIMETHYL FUMARATETERIFLUNOMIDE

Drug Class

Other

DMARD

Route

Oral

Half-Life

—

FDA Approved

—

Side Effect Frequency Comparison

Estimated frequency (%) based on clinical trial data

Side Effects

DIMETHYL FUMARATE

Nausea

1-10%

Diarrhea

1-10%

Fatigue

1-10%

Vomiting

1-10%

Drug Not Working

1-10%

Headache

0.1-1%

Itching

0.1-1%

Falls

0.1-1%

TERIFLUNOMIDE

Hair Loss

>10%

Fatigue

1-10%

Diarrhea

1-10%

Falls

1-10%

Headache

1-10%

Drug Not Working

1-10%

Tingling/Numbness

1-10%

Nausea

1-10%

FDA Warnings

DIMETHYL FUMARATE

5 WARNINGS AND PRECAUTIONS Anaphylaxis and angioedema: Discontinue and do not restart dimethyl fumarate if these occur
2 ) Herpes zoster and other serious opportunistic infections: Consider withholding dimethyl fumarate in cases of serious infection until the infection has resolved
PML is an opportunistic viral infection of the brain caused by the JC virus (JCV) that typically only occurs in patients who are immunocompromised, and that usually leads to death or severe disability
A fatal case of PML occurred in a patient who received dimethyl fumarate for 4 years while enrolled in a clinical trial

TERIFLUNOMIDE

5 WARNINGS AND PRECAUTIONS • Elimination of teriflunomide tablets can be accelerated by administration of cholestyramine or activated charcoal for 11 days
Consider suspending treatment with teriflunomide tablets in case of serious infection
Patients with pre-existing liver disease and patients taking other hepatotoxic drugs may be at increased risk for developing liver injury when taking teriflunomide tablets
Teriflunomide tablets are contraindicated in patients with severe hepatic impairment [see Contraindications (4) ]

Clinical Trial Data

No head-to-head clinical studies found for DIMETHYL FUMARATE vs TERIFLUNOMIDE.

DIMETHYL FUMARATE vs TERIFLUNOMIDE: What You Should Know

Key Differences

Shared Indications

Safety Considerations

This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.