Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare DULOXETINE (DULOXETINE HYDROCHLORIDE) and FLUOXETINE (Fluoxetine) — clinical data, side effects, and patient experiences.
DULOXETINE HYDROCHLORIDE, Cymbalta · SNRI
How it works
12.1 Mechanism of Action Although the exact mechanisms of the antidepressant, central pain inhibitory and anxiolytic actions of duloxetine in humans are unknown, these actions are ...
Approved for
Fluoxetine, Prozac · SSRI
How it works
12.1 Mechanism of Action Although the exact mechanism of fluoxetine is unknown, it is presumed to be linked to its inhibition of CNS neuronal uptake of serotonin.
Approved for
Estimated frequency (%) based on clinical trial data
Based on 28 Reddit discussions
DULOXETINE
27%
positive
15 threads
FLUOXETINE
38%
positive
13 threads
% of discussions mentioning each side effect
15 Reddit threads analysed for DULOXETINE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
43 upvotes
Most discussed side effects in community
I am a 28 year old man and I've just realized that nothing interests me. I believe that it might be connected to depression as I am on medication for depression and anxiety (duloxetine) I am not really sad or anything. I am just very neutral. Things that used to interest, excite me and make me happ
I have been recovering from over a decade of major depressive disorder and recently diagnosed bipolar II. I’m seeing light at the end of the tunnel with Lamotrigine and lifestyle changes, and after several mental health evaluations, my psychiatrist gave me the best news ever; I can stop taking antid
Hi, just wondering if this is a common experience: So i've been taking agomelatine 50mg for about 5 months and duloxetine 60mg for 3 months now for severe depression and anxiety. The antidepressants have been working just as intended in the sense that most of the mental agony has gone, but there's
I ( M23) have been taking duloxetine 60 mg for 2 years now. While it has helped tremendously with my anxiety/depression/DPDR, it did cause sexual side effects for me. (I also take lamotrigine, but that is unlikely to cause effects like this) For me, these sides were very annoying; my main problem wa
Entry time 8:55am Before I went to sleep last night, I had nurses come 2 times, around 9:30pm and then at 10:40pm asking if I wanted to take some anxiety medication to help me sleep better. I refused both times as it wasn't initially prescribed, and in general I don't have a problem sleeping. My al
UHC is canceling coverage of my medication: Lamotrigine, Atomoxetine, and Duloxetine. Starts in January. Im barely getting by as it is. I need to find new insurance asap (Im in the USA). Its no wonder they were targeted. I just learned that they deny the most coverage of any US health insurer. Wtf a
Since the late of 2019 year, till now I've tried: 1- Escitalopram "Lexapro" (tried Atomoxetine "Strattera" with it, then stopped it due to its bad effects) (tried Risperidone "Rispardal" then stopped it, it hasn't only bad effects, but also highly increased prolactin) 2- Fluoxetine "Prozac" 3- Bupro
You know how a lot of sources say working towards a goal and then achieving it gives a sense of reward via dopamine? This week I got a pay rise, achieved a fitness goal I've been working towards for months and even got asked out on a date by someone quite attractive. But I feel absolutely nothing.
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
13 Reddit threads analysed for FLUOXETINE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
185 upvotes
Most discussed side effects in community
I am depression. The person I used to be is gone, there is no going back from this. I'm just sat In the hospital while my mum speaks to cahms, trying to hide my neck from all the other patients. I'm desperate to leave the hospital and get home but I know I'm gonna try again eventually. I've been on
Started seeing a therapist in April 2013 because my mum was worried about me. The therapist was in her mid 20's, and was pretty, so I felt a level of attraction to her, and told her a lot of things about me that I hadn't told anyone. I was in high school at the time, an all boys one, so she was basi
Hello everyone, my name is Samuel, I'm 14 years old and I'm Brazilian. I've been having these thoughts for about two or three years, but in the last few days they've gotten a lot worse. especially after I started taking fluoxetine I think about suicide all day and it haunts me all the time, I can'
I feel like the anti-anxiety effects of this drug (Fluoxetine AKA Prozax), which have been good in a lot of ways, have caused me to lose a certain sense of 'urgency' or 'appropriate' anxiety towards things like academic deadlines etc. Things I really should be worrying about don't really make me anx
Hi! hope someone who is not feeling good read this. I tried to commit suicide two years ago. in fact, using another reddit account I found help with this community before, and people was really nice!.. So now I want to write this just to i dunno... maybe put some hope in at least someone. I've bee
A brief summary: so I had major depression & severe for anxiety for about 1.5yrs, it was serious & I was at an all time low, hospital admissions, the lot. Doctors suspected it was drug induced (from MDMA), which I completely agree with, it was the time I spiralled down HARD, and also situati
I am on 20mg of fluoxetine and it’s stopping me from crying almost completely, I can occasionally squeeze out a tear or two and I’ve had one been breakdown when I was drunk but other than that the feelings build in my body and I feel worse and worse but it has nowhere to go. I’m also breaking out in
7 months ago, I took fluoxetine for a total of 14 days, after a period of mild depression. Although far from being perfectly stable, I was still an energetic, passionate, intelligent young man with big aspirations and a lot to live for. Those 14 pills changed all of that. After about a week on the m
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
DULOXETINE is a SNRI, while FLUOXETINE belongs to the SSRI class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles.
Both medications are approved for See full prescribing information. When two drugs treat the same condition, the choice between them often depends on the patient's medical history, other medications, tolerability, and prescriber preference.
DULOXETINE carries 4 FDA warnings. FLUOXETINE carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.