Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare DULOXETINE (DULOXETINE HYDROCHLORIDE) and MIRTAZAPINE (Mirtazapine) — clinical data, side effects, and patient experiences.
DULOXETINE HYDROCHLORIDE, Cymbalta · SNRI
How it works
12.1 Mechanism of Action Although the exact mechanisms of the antidepressant, central pain inhibitory and anxiolytic actions of duloxetine in humans are unknown, these actions are ...
Approved for
Mirtazapine, Remeron, Zispin · Atypical Antidepressant
How it works
12.1 Mechanism of Action The mechanism of action of mirtazapine for the treatment of major depressive disorder, is unclear. However, its efficacy could be mediated through its acti...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 30 Reddit discussions
DULOXETINE
27%
positive
15 threads
MIRTAZAPINE
33%
positive
15 threads
% of discussions mentioning each side effect
15 Reddit threads analysed for DULOXETINE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
43 upvotes
Most discussed side effects in community
I am a 28 year old man and I've just realized that nothing interests me. I believe that it might be connected to depression as I am on medication for depression and anxiety (duloxetine) I am not really sad or anything. I am just very neutral. Things that used to interest, excite me and make me happ
I have been recovering from over a decade of major depressive disorder and recently diagnosed bipolar II. I’m seeing light at the end of the tunnel with Lamotrigine and lifestyle changes, and after several mental health evaluations, my psychiatrist gave me the best news ever; I can stop taking antid
Hi, just wondering if this is a common experience: So i've been taking agomelatine 50mg for about 5 months and duloxetine 60mg for 3 months now for severe depression and anxiety. The antidepressants have been working just as intended in the sense that most of the mental agony has gone, but there's
I ( M23) have been taking duloxetine 60 mg for 2 years now. While it has helped tremendously with my anxiety/depression/DPDR, it did cause sexual side effects for me. (I also take lamotrigine, but that is unlikely to cause effects like this) For me, these sides were very annoying; my main problem wa
Entry time 8:55am Before I went to sleep last night, I had nurses come 2 times, around 9:30pm and then at 10:40pm asking if I wanted to take some anxiety medication to help me sleep better. I refused both times as it wasn't initially prescribed, and in general I don't have a problem sleeping. My al
UHC is canceling coverage of my medication: Lamotrigine, Atomoxetine, and Duloxetine. Starts in January. Im barely getting by as it is. I need to find new insurance asap (Im in the USA). Its no wonder they were targeted. I just learned that they deny the most coverage of any US health insurer. Wtf a
Since the late of 2019 year, till now I've tried: 1- Escitalopram "Lexapro" (tried Atomoxetine "Strattera" with it, then stopped it due to its bad effects) (tried Risperidone "Rispardal" then stopped it, it hasn't only bad effects, but also highly increased prolactin) 2- Fluoxetine "Prozac" 3- Bupro
You know how a lot of sources say working towards a goal and then achieving it gives a sense of reward via dopamine? This week I got a pay rise, achieved a fitness goal I've been working towards for months and even got asked out on a date by someone quite attractive. But I feel absolutely nothing.
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
15 Reddit threads analysed for MIRTAZAPINE
Overall Sentiment
Mixed
Comparison Threads
1
Avg Post Score
77 upvotes
Most discussed side effects in community
Threads directly comparing MIRTAZAPINE to other medications
http://i.imgur.com/5Gcb8.jpg A year ago, I was sitting in the middle of class and just up and decided I wanted to be dead, so I got on the next bus to the train station. A man saw me crying and sat next to me and asked me what was wrong, I told him what I was going to do because, well who gives a sh
In this post I'm going to give you a bunch of tips that can help you with your anxiety and depression and not only that but explain some of the science behind it in a way that's easy to understand. I've had anxiety and depression for 15 years and have tried a huge array of medications, tried differe
SSRIs didn't do shit. Nor mirtazapine. Nor CBT. Nor counselling. Nor even stimulants now. I genuinely despise the words "attitude" and "mindset" and wish to see them permanently expunged from the English vocabulary. Incidentally, none of the counsellors or therapists I've seen over the years have us
What happens next? I facelessly type my problems into the internet and hope that strangers will be able to change my outlook or something. I'm not sure what I actually fucking expect. I'm just lonely and scared and tired. UPDATE: Thank you so much everyone for the kind words, advice and just letting
Hey all. I was officially diagnosed with depression and anxiety about 2 years ago. But I was a stubborn person back then and refused to have any meds. I even stopped therapy after a while. Fast forward to the last week, I restarted therapy and the new doc has prescribed me Mirtazapine for the time b
If you're anything like me, when I am looking into a new drug or beginning to take a new drug I go to the internet to look for common side-effects and other people's personal experiences. I'm bored so I am going to write out my experience/s with Mirtazapine over the last 3 years for anyone looking i
This February marks the end of my (27M) 3rd year on Remeron / Mirtazapine, a non-SSRI antidepressant. Reddit was the only reason I even asked about it, so I’m posting a review for anyone thinking about starting antidepressants, who also might be scared of the side effects many people experience with
I started taking the antidepressant Mirtazapine back in late August. It was to help manage my depression and anxiety. I can't really speak to its effect on those two issues, but I had another issue: chronic, intractable migraines every day that lasted hours upon hours. And the Mirtazapine completely
January marks my 1 year on Mirtazapine, and it has been incredible for me! I have suffered from pretty bad panic attacks and depression since I was 13, and was never medicated (with an antidepressant) till a year ago. It was the perfect drug for me, as I struggle to sleep at night and needed to gai
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
DULOXETINE is a SNRI, while MIRTAZAPINE belongs to the Atypical Antidepressant class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles.
Both medications are approved for See full prescribing information. When two drugs treat the same condition, the choice between them often depends on the patient's medical history, other medications, tolerability, and prescriber preference.
DULOXETINE carries 4 FDA warnings. MIRTAZAPINE carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.