Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare DULOXETINE (DULOXETINE HYDROCHLORIDE) and NAPROXEN (Naproxen) — clinical data, side effects, and patient experiences.
DULOXETINE HYDROCHLORIDE, Cymbalta · SNRI
How it works
12.1 Mechanism of Action Although the exact mechanisms of the antidepressant, central pain inhibitory and anxiolytic actions of duloxetine in humans are unknown, these actions are ...
Approved for
Naproxen, Aleve, Naprosyn · NSAID
How it works
12.1 Mechanism of Action Naproxen has analgesic, anti-inflammatory, and antipyretic properties. Naproxen sodium has been developed as a more rapidly absorbed formulation of naproxe...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 30 Reddit discussions
DULOXETINE
27%
positive
15 threads
NAPROXEN
20%
positive
15 threads
% of discussions mentioning each side effect
15 Reddit threads analysed for DULOXETINE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
43 upvotes
Most discussed side effects in community
I am a 28 year old man and I've just realized that nothing interests me. I believe that it might be connected to depression as I am on medication for depression and anxiety (duloxetine) I am not really sad or anything. I am just very neutral. Things that used to interest, excite me and make me happ
I have been recovering from over a decade of major depressive disorder and recently diagnosed bipolar II. I’m seeing light at the end of the tunnel with Lamotrigine and lifestyle changes, and after several mental health evaluations, my psychiatrist gave me the best news ever; I can stop taking antid
Hi, just wondering if this is a common experience: So i've been taking agomelatine 50mg for about 5 months and duloxetine 60mg for 3 months now for severe depression and anxiety. The antidepressants have been working just as intended in the sense that most of the mental agony has gone, but there's
I ( M23) have been taking duloxetine 60 mg for 2 years now. While it has helped tremendously with my anxiety/depression/DPDR, it did cause sexual side effects for me. (I also take lamotrigine, but that is unlikely to cause effects like this) For me, these sides were very annoying; my main problem wa
Entry time 8:55am Before I went to sleep last night, I had nurses come 2 times, around 9:30pm and then at 10:40pm asking if I wanted to take some anxiety medication to help me sleep better. I refused both times as it wasn't initially prescribed, and in general I don't have a problem sleeping. My al
UHC is canceling coverage of my medication: Lamotrigine, Atomoxetine, and Duloxetine. Starts in January. Im barely getting by as it is. I need to find new insurance asap (Im in the USA). Its no wonder they were targeted. I just learned that they deny the most coverage of any US health insurer. Wtf a
Since the late of 2019 year, till now I've tried: 1- Escitalopram "Lexapro" (tried Atomoxetine "Strattera" with it, then stopped it due to its bad effects) (tried Risperidone "Rispardal" then stopped it, it hasn't only bad effects, but also highly increased prolactin) 2- Fluoxetine "Prozac" 3- Bupro
You know how a lot of sources say working towards a goal and then achieving it gives a sense of reward via dopamine? This week I got a pay rise, achieved a fitness goal I've been working towards for months and even got asked out on a date by someone quite attractive. But I feel absolutely nothing.
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
15 Reddit threads analysed for NAPROXEN
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
204 upvotes
Most discussed side effects in community
Going to a small get-together for new years, and the poison ring I bought myself came in JUST in time! Cant wait to discreetly take my mid-party naproxen without having to fish through my purse! Happy new year everyone, may 2026 hurt less than 2025 🥳
I have so much wrong with me. Like it’s genuinely whole body at this point. Back pain, internal tremors, migraines, stomach issues, fatigue, heart palpitations, dysautonomia, rib pain, brain fog, vertigo, muscle inflammation, hands aching, pain that covers my whole body, knees hurting. I could keep
I'm hypermobile and fat and this has caused me to develop osteoarthritis in my hip, normal NSAIDs don't work on me and I'm allergic to naproxen. I'm scared of becoming addicted to opioids because they seem to be the only thing that helps but I've already gotten 2 prescriptions of them and I'm curren
This is more of a rant I guess. I've been struggling with pain for over a decade now, and no matter how bad it gets, I'm given naproxen or acetaminophen. Naproxen doesn't work for me, and it requires high doses of acetaminophen for me to get a small amount of relief. But they are still the only pai
Had a flare up today and usually when this happens I can’t walk. I usually end up in the ER because when I call my doctor I always get “we can’t help you unless you come in” Ma’am you diagnosed me and all I need is a steroid pack and some naproxen to reduce swelling. So when I was finally mobile eno
one more time. I’m going to scream. Anyone with me?
I have chronic pain along with fatigue and other issues and a majority of my pills are for my pain my doctors are trying me on so much before actually giving me anything to relieve the pain. I asked for 500mg naproxen and was given a muscle relaxer to take 3 times a day i’m up to at least 12 pills a
Hey everyone! I’ve been seeing a lot of posts lately in this sub and in others about people asking for little things that help manage the pain, so I thought I’d compile a list of stuff that helps me and others can tack on what helps them in the comments. I hope someone finds this useful! - **Prescri
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
DULOXETINE is a SNRI, while NAPROXEN belongs to the NSAID class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles.
Both medications are approved for See full prescribing information. When two drugs treat the same condition, the choice between them often depends on the patient's medical history, other medications, tolerability, and prescriber preference.
DULOXETINE carries 4 FDA warnings. NAPROXEN carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.