Compare DUPILUMAB (Dupixent) and UPADACITINIB (Rinvoq) — clinical data, side effects, and patient experiences.
Dupixent · Biologic (Asthma/Allergy)
How it works
12.1 Mechanism of Action Dupilumab is a human monoclonal IgG4 antibody that inhibits interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling by specifically binding to the IL-4Rα...
Approved for
Rinvoq · JAK Inhibitor
How it works
12.1 Mechanism of Action Upadacitinib is a Janus kinase (JAK) inhibitor. JAKs are intracellular enzymes which transmit signals arising from cytokine or growth factor-receptor inter...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 24 Reddit discussions
DUPILUMAB
40%
positive
10 threads
UPADACITINIB
64%
positive
14 threads
% of discussions mentioning each side effect
10 Reddit threads analysed for DUPILUMAB
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
108 upvotes
Most discussed side effects in community
disclaimer: eczema is a very individual disease with different causes and triggers for every person. what works for me might not work for you and what didn’t work for me might work for you. just keep that in mind! though i do encourage trying out different things that are not steroids or medical pre
A few years ago, my eczema was severe. I had open weeping wounds all over my body, skin shedding 24/7, no eyebrows, peeling scalp, everything you can imagine. I barely looked human. I'm now 95% normal. I have plenty of scars and hyperpigmentation as a reminder, but aside from random inflammation, I'
So long story short… Big fat eczema flare up. Huge. Spreads over my hands and down my legs. Bleeding when I walk. All over face and chest and cannot leave the house. Call GP, crying my eyes out. Say I’m on the verge of killing myself. Please help me. GP : no, no. Stop crying. STOP CRYING. You won’
I think I honestly just want to rant and talk to some like minded people, maybe those that lead somewhat of a normal life (working, relationships, social interaction) I've suffered severe atopic dermatitis since I was 13, by the time I was 16 it covered every inch of my body and face, during a time
Had severe eczema my entire life (along with severe asthma, yay, severe allergies, yay). Remember back in 2017ish posts about Dupilumab on this forum (and others) from people in the US who were part of the trial saying it was a game changer, as good as steroids (orally, not creams). It got me excite
Sup guys. New here. I (23m) have severe eczema and I've been prescribed everything under the sun: topical steroids, protopic, methotrexate, phototherapy, dupilumab and even homeopathy (my mother is one of those fruitloops, didn't work, ended up in hospital). What I'm saying is that all my mates kind
I've suffered with some really awful eczema for the last 7 years, developing it in middle age. I've been on every oral eczema medication with all the possible side effects, every topical steroid and protopic, tried a very austere diet for 7 months eliminating virtually every possible trigger food.
My dermatologist rang me this morning and told me my application for dupilumab/dupixent got approved and the prescription will be sent to my pharmacy. In my country, I will have to pay €80 a month for a month worth of the drug and the rest is subsidised by the healthcare system. I feel so relieved a
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
14 Reddit threads analysed for UPADACITINIB
Overall Sentiment
Slightly positive
Comparison Threads
0
Avg Post Score
30 upvotes
Most discussed side effects in community
For context: for pretty much all of last year over 80% of my body was covered in eczema rash. It was so severe I couldn't use the shower and had to either take baths or wash myself in the sink. My scalp was constantly peeling and I was *always* itchy. While my skin would get better in summer, it was
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Hey everyone! I just wanted to provide some sort of update having been on Upadacitinib for just over a month. My eczema is gone and I no longer need to take cold showers and I don't even need to moisturise after showers. My skin looks healthy and clear it is so surreal. This medication is not a ste
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I am interested in participating in a clinical trial. I am leaning towards the 3 mentioned in the title, though I would love to hear about any others that seem promising. I am hoping there will be phase 3 trials in my area some time in the first half of 2018 for ABT-494 and PF-04965842. Phase 3 for
About 80% of my body was covered when I went to the dermatologist, so he sent me to hospital for inpatient treatment for 5 days. I did a paraffin bath -> topical steroid -> wet wrap -> emollient treatment twice a day and everything has cleared up. I've been given a metric tonne of moisturiz
Almost a year ago, after years of worsening Atopic Dermatitis, i said enough is enough, and decided to buy Upadacitinib, a JAK inhibitor originally used for rheumatoid arthritis, after reading about very promising clinical trials for AD. When i posted about it many of you guys were surprised about
Hi there, I wanted to share my experience with eczema and how, in the past 1.5 years, these drugs changed my life: **Growing up and coping:** I’ve had eczema since I was six years old. It started on my elbows, ankles, and on my thigh where I had operations as a child. Around 10 or 11, it spread. I t
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
DUPILUMAB is a Biologic (Asthma/Allergy), while UPADACITINIB belongs to the JAK Inhibitor class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles. DUPILUMAB is administered via Subcutaneous, whereas UPADACITINIB uses Oral. Route of administration can affect onset of action and patient adherence.
DUPILUMAB carries 2 FDA warnings. UPADACITINIB carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.
Every figure on this comparison links back to its primary source. See data sources and methodology for the full provenance trail.