Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare EMPAGLIFLOZIN (JARDIANCE) and PIOGLITAZONE (Pioglitazone) — clinical data, side effects, and patient experiences.
JARDIANCE, Jardiance, Synjardy · SGLT-2 Inhibitor
How it works
12.1 Mechanism of Action Empagliflozin is an inhibitor of the sodium-glucose co-transporter 2 (SGLT2), the predominant transporter responsible for reabsorption of glucose from the ...
Approved for
Pioglitazone, Actos, Actoplus Met · Thiazolidinedione
How it works
12.1 Mechanism of Action Pioglitazone is a thiazolidinedione that depends on the presence of insulin for its mechanism of action. Pioglitazone decreases insulin resistance in the p...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 30 Reddit discussions
EMPAGLIFLOZIN
20%
positive
15 threads
PIOGLITAZONE
40%
positive
15 threads
% of discussions mentioning each side effect
15 Reddit threads analysed for EMPAGLIFLOZIN
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
13 upvotes
Most discussed side effects in community
I have my monthly checkup soon and my lab test came (finally) under 6 after 4 months of daily exercise and low carb diet (im currently just taking 25 mg empagliflozin). So incredibly grateful for this community and working towards managing it without any medications. 🥲 I will be celebrating with
I’ve been T2 for 10+ years and I was diagnosed at a pretty young age (21), so it’s really something I’ve been living with for my whole adult life, and over that time my treatment has changed, and new medications have been added where it’s been needed to help keep my levels under control. My GP has r
**So an Update: I asked my primary care doctor that I wanted to go and see an endocrinologist. I got told that I do not qualify to see one. She claims I am a diabetic but I can't go and see a endocrinologist.** So, went to my doctor at the VA end of last month. Had blood work done. No one told me
I just read in an article that someone was paying over $500 a month for that single drug alone. How in the hell do you poor US citizens manage your healthcare costs? It's difficult for me to get my head around tbh
I was diagnosed with diabetes roughly 3 weeks ago with an HBA1c of 12 and prescribed metformin xr, empagliflozin, sitagliptin, and got a cgm as well. Changed my diet abruptly and removed all food with added sugars and bad carbs and I found out doing IF 16/8 helps as well. Also added exercise through
In the last few months, I’ve been stress-eating and fully aware that my lifestyle is incredibly unhealthy. Despite knowing better, I didn’t care so much, overwhelmed by stress from work and my personal life. As a result, I started experiencing the usual symptoms—feeling thirsty and frequently needin
The warnings for Jardiance (Empagliflozin) include this statement Jardiance may increase the risk of lower limb amputation (especially of the toe and foot). The risk is higher if you have poor blood flow in the legs, nerve problems, foot ulcers, or have had a previous amputation. To lessen the risk
I recently spent four months doing a clinical trial with Empagliflozin. This is my experience and I want as many Type I's to see it as possible. I am writing this post in order to spread the word about its effectiveness in my case. It is not currently prescribed to Type I’s because there is risk of
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
15 Reddit threads analysed for PIOGLITAZONE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
25 upvotes
Most discussed side effects in community
I was Diagnosed 7 months ago. I'm 5'7", and I weighed 260 lbs (Obese Class III). Lab results showed: * A1C of 11.2 * non alcoholic fatty liver * high blood pressure (hypertension stage 2) * high cholesterol I was prescribed Mounjaro, pioglitazone, amlodipine, and rosuvastatin. At my follow up appoin
Was diagnosed type-2 on November 11th, which was the first day I tested. My very first test was above 280. I made a post here a few weeks ago that my highest was 380. After that, I made an aggressive change to my diet(Tuna mixes with veggies and a bit of cream cheese on low carb wraps are god like),
been on insulin for 6 month . i turned my health around in a short time 12.9 a1c to 5.4 a1c ( made a post a month ago about that ). well at today check up docotor said i can fully stop all insulin and just keep taking metformin and Pioglitazone and i no longer need to come back in every 3 months
Hi I’m Rosa and I don’t know what I’m doing, Ok back story as concise as I can: -When I was 15 in was diagnosed with PCOS and was told that I would have insulin resistance because of it. -I was put on metformin to help with it but I can’t tolerate it, I’m constantly sick to my stomach on it -
I'm already down to 6.0. A 3.5% drop. Like I'm right at the cusp of being at the finish line (I know it's not the end, and that I have to stay there) of getting out of the "Complication Range" Went from a dangerous level down to the middle of Pre-diabetic in only 3 months. Also, my average, if going
I've been diabetic ever since I had my son 3 years ago. I'm the type that has no clue when my BS is running high; I can only ever tell when it's low, but that hasn't happened in a while. I know I need to get my shit together and work on reversing this but it's so hard. I'm not sure why it's so hard
On January 19 I was tested by my doctor and confirmed I was t2 diabetic with an a1c of 10.4. I just got my lab results from the blood test on April 21, that my a1c is now 5.3!!!!!!! I didn't just diet - I made a life change. I worked with a nutritionalist, counted carbs and proteins, cooked every m
Disclaimer: I’m not looking for medical advice. I’m aware information contained in this post does not give anyone enough information for any kind of diagnosis. 54 y/o male, 5’7”, SW 260, CW 228. Three months ago I had my first doctor’s appointment in 7 years. My A1C results were bad (11.2%), and I
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
EMPAGLIFLOZIN is a SGLT-2 Inhibitor, while PIOGLITAZONE belongs to the Thiazolidinedione class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles.
Both medications are approved for See full prescribing information. When two drugs treat the same condition, the choice between them often depends on the patient's medical history, other medications, tolerability, and prescriber preference.
EMPAGLIFLOZIN carries 4 FDA warnings. PIOGLITAZONE carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.