ENTACAPONE vs RASAGILINE

Compare ENTACAPONE (Entacapone) and RASAGILINE (RASAGILINE) — clinical data, side effects, and patient experiences.

ENTACAPONE

Entacapone · Parkinson's Agent

How it works

Mechanism of Action Entacapone is a selective and reversible inhibitor of COMT. In mammals, COMT is distributed throughout various organs with the highest activities in the liver a...

Approved for

INDICATIONS AND USAGE Entacapone tablets USP are indicated as an adjunct to levodopa and carbidopa to treat end-of-dose "wearing-off" in patients with Parkinson's disease (see CLINICAL PHARMACOLOGY

Clinical Studies ). Entacapone's effectiveness has not been systematically evaluated in patients with Parkinson's disease who do not experience end-of-dose "wearing-off".

OralTablet

RASAGILINE

RASAGILINE · Parkinson's Agent

How it works

Other agent

Approved for

1 INDICATIONS AND USAGE Rasagiline tablets are indicated for the treatment of Parkinson's disease (PD). Rasagiline Tablets

a monoamine oxidase (MAO)-B inhibitor (MAOI)

is indicated for the treatment of Parkinson's disease ( 1 )

OralTablet

Quick Comparison

ENTACAPONERASAGILINE

Drug Class

Parkinson's Agent

Route

Oral

Half-Life

—

FDA Approved

—

Pregnancy

—

Side Effect Frequency Comparison

Estimated frequency (%) based on clinical trial data

Side Effects

ENTACAPONE

Falls

>10%

Drug Not Working

1-10%

Tremor

1-10%

Drowsiness

0.1-1%

Constipation

0.1-1%

Fatigue

0.1-1%

Nausea

0.1-1%

Dizziness

0.1-1%

RASAGILINE

Falls

>10%

Drug Not Working

1-10%

Tremor

1-10%

Dizziness

1-10%

Drowsiness

1-10%

Nausea

1-10%

Fatigue

1-10%

Constipation

0.1-1%

FDA Warnings

ENTACAPONE

WARNINGS Monoamine oxidase (MAO) and COMT are the two major enzyme systems involved in the metabolism of catecholamines
Falling Asleep During Activities of Daily Living and Somnolence Patients with Parkinson's disease treated with entacapone, which increases plasma levodopa levels, or with levodopa have reported suddenly falling asleep without prior warning of sleepiness while engaged in activities of daily living (including the operation of motor vehicles)
Although many of these patients reported somnolence while on entacapone, some did not perceive warning signs, such as excessive drowsiness, and believed that they were alert immediately prior to the event
The risk of somnolence was increased (entacapone 2% and placebo 0%) in controlled studies

RASAGILINE

5 WARNINGS AND PRECAUTIONS May cause hypertension (including severe hypertensive syndromes) at recommended doses (5
When used as an adjunct to levodopa (Studies 3 and 4), the risk for developing post-treatment high blood pressure (e
Rasagiline is contraindicated for use with meperidine, tramadol, methadone, propoxyphene and MAO inhibitors (MAOIs), including other selective MAO-B inhibitors [see Contraindications (4) and Drug Interactions (7
Serotonin syndrome can result in death

Community Sentiment Analysis

Based on 8 Reddit discussions

ENTACAPONE

positive

8 threads

RASAGILINE

positive

0 threads

Community-Reported Side Effects

% of discussions mentioning each side effect

Community Discussions

8 Reddit threads analysed for ENTACAPONE

Overall Sentiment

Mixed

Comparison Threads

Avg Post Score

8 upvotes

Most discussed side effects in community

Fatigue (2)

Stomach Pain (1)

Weight Gain (1)

Rash (1)

Brain Fog (1)

Patient Experiences (r/pharmacy, r/AskDocs & more)

Mom has Parkinson’s and is doing so poorly. I don’t know how to help.

I apologize if this is long. I truly do not know where else to go. My mom is 68. She was diagnosed with Parkinson’s in 2016 but may have had it a couple years before then. They do believe she has Parkinson’s dementia. She is on carbidopa and just started entacapone as the wearing off was very bad.

r/Parkinsons20102y ago

My Dad just started taking entacapone, to help with wearing off symptoms of PD. Anyone else have any experience with thi…

He’s just been prescribed this and am slowly phasing it in so he’ll be on 3 tablets a day on top of current meds. Not sure if they are helping much so far and also whether he’s just having a bad week, or the side effects are showing their lovely selves. I was told they could make him more confused a

r/Parkinsons10106y ago

Fatigue

Stomach Pain

How to deal with my father’s “Parkinson’s.”

Edit: Posted this in the wrong subreddit, mods took it down and made me post it over here. Made this post last night. Here is my life story and background into my experience with being a Parkinson’s caregiver. And I have about had it. Basically asking for any pointers/tips/help at this point. I (F23

r/ParkinsonsCaregivers7158mo ago

Rytary

I was diagnosed 2 years ago. Stuffness in my right extremities. Have been taking Rytary with entacapone and sometimes I feel like the meds do nothing. I haven't really progressed according to my neurologist. I exercise every day. 4 days a week of running and 3 of weight lifting. Anyone had a simila

r/Parkinsons7201y ago

My neurologist just prescribed me entacapone to help my L-dopa , but it is not working, the worst part, stiffness and we…

r/Parkinsons6341y ago

Entacapone: Have you tried it? Did it help?

At this week's checkup the MDS asked if I wanted to try entacapone for extending 'on' time. We already do a mix of regular and ER C/L. Her only concern was that it might worsen issues with excessive daytime sleepiness. If you've tried it, or if you provide care to someone who has, what was the exper

r/Parkinsons5218mo ago

Sudden worsening freezing of gait after med change (entacapone) – anyone experienced this?

Hi everyone – hoping to get some perspective from others who’ve been through similar medication changes with Parkinson’s. My dad was diagnosed with Parkinson’s about 2 years ago. His pattern has mostly been motor-predominant PD with freezing of gait (FOG) as his main issue – especially when starting

r/Parkinsons453mo ago

I am lost. I’ve gone down a million rabbit holes. I fell victim to the 10x gene test and wish I would have done more com…

I have been on this new ‘journey’ for months now. I am 6 months postpartum with my third child and about 3 months ago I developed rashes around my eyes and all over my arms and hands. I had sudden weight gain/inflammation. Went to check basic labs and of course everything was ‘normal’. Went back 2 w

r/MTHFR4132y ago

Fatigue

Weight Gain

Rash

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

Community Discussions

No community discussions found for RASAGILINE yet.