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Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare Escitalopram (Lexapro) and Levomilnacipran (Fetzima) — clinical data, side effects, and patient experiences.
Lexapro, Celexa, Cipramil · SSRI (Selective Serotonin Reuptake Inhibitor)
How it works
The S-enantiomer of citalopram. Selectively inhibits serotonin reuptake with minimal effects on norepinephrine and dopamine. More selective and potent than racemic citalopram.
Approved for
Fetzima · SNRI
How it works
SNRI with preferential norepinephrine reuptake inhibition over serotonin, providing antidepressant and functional improvement effects.
Approved for
Estimated frequency (%) based on clinical trial data
No specific warnings
Based on 21 Reddit discussions
Escitalopram
33%
positive
15 threads
Levomilnacipran
50%
positive
6 threads
% of discussions mentioning each side effect
Based on 1 verified patient review
No data yet
No data yet
Avg. Duration
8 months
100% still taking
Avg. Duration
0 months
0% still taking
Escitalopram is a SSRI (Selective Serotonin Reuptake Inhibitor), while Levomilnacipran belongs to the SNRI class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles.
Both medications are approved for Major Depressive Disorder. When two drugs treat the same condition, the choice between them often depends on the patient's medical history, other medications, tolerability, and prescriber preference.
Escitalopram has an average efficacy rating of 9.0/10 and tolerability of 7.0/10 across 1 patient review. Patient-reported outcomes provide real-world context beyond clinical trials, though individual responses to medication vary significantly..
Escitalopram carries 3 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.