Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare GUSELKUMAB (TREMFYA) and UPADACITINIB (Rinvoq) — clinical data, side effects, and patient experiences.
TREMFYA, Tremfya · Biologic (IL-23 Inhibitor)
How it works
12.1 Mechanism of Action Guselkumab is a human monoclonal IgG1λ antibody that selectively binds to the p19 subunit of interleukin 23 (IL-23) and inhibits its interaction with the I...
Approved for
Rinvoq · JAK Inhibitor
How it works
12.1 Mechanism of Action Upadacitinib is a Janus kinase (JAK) inhibitor. JAKs are intracellular enzymes which transmit signals arising from cytokine or growth factor-receptor inter...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 30 Reddit discussions
GUSELKUMAB
27%
positive
15 threads
UPADACITINIB
60%
positive
15 threads
% of discussions mentioning each side effect
15 Reddit threads analysed for GUSELKUMAB
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
29 upvotes
Most discussed side effects in community
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Hi everyone, first, just want to thank everyone for sharing in this forum, for the courage to reveal and be vulnerable, for providing a sense of community and connection when its easy to feel alone in what we're struggling with, and for the encouragement and support. About me: 51yo male with recen
I use the biologic in the photo. My doctor gave me the first injection, and today I have to do the second injection by myself. I wanted to ask if you inject yourself? Is it easy? I
My gf has been prescribed to get Secukinumab (Scapho) for 5 weeks, then monthly after, and Guselkumab (Tremfya) once a month (afaik this is conditional to her response to Scapho in the first 4 weeks). She's being charged 32k for Secukinumab and 82k for Guselkumab per session. Are there any availabl
So..we don't exactly know for sure even whether the injection had a direct effect or was merely acting on the gut microbiome which then quenched the inflammation. # Compositional Alteration of Gut Microbiota in Psoriasis Treated with IL-23 and IL-17 Inhibitors [Yu-Huei Huang](https://pubmed.ncbi.nl
Hi All, I was able to join a clinical trial for Guselkumab and had my first dose 3-4 weeks ago. Just wondering if any of you had experienced an onset of Migraine as a side effect of the medicine? Also, maybe more acne? Thanks!
***EDIT: I am in the US. I have my next GI follow up to likely begin Tremfya on 10/7. I did my labs today for calprotectin, TB, HIV, CBC, CMP, Hepatitis, and TPMT activity. Hi everyone, I stopped into my GI today and got copies of my colonoscopy, biopsy, and follow-up visit note with my GI from las
I was diagnosed with Psoriasis last March 2024. 3 months later, I started Guselkumab (Tremfya). Since then, my skin really cleared up. No flares. I feel normal and back with my old self except that I have hyperpigmentation on some areas but not really a big problem. Been taking this biologic for 8 m
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
15 Reddit threads analysed for UPADACITINIB
Overall Sentiment
Slightly positive
Comparison Threads
0
Avg Post Score
29 upvotes
Most discussed side effects in community
For context: for pretty much all of last year over 80% of my body was covered in eczema rash. It was so severe I couldn't use the shower and had to either take baths or wash myself in the sink. My scalp was constantly peeling and I was *always* itchy. While my skin would get better in summer, it was
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Hey everyone! I just wanted to provide some sort of update having been on Upadacitinib for just over a month. My eczema is gone and I no longer need to take cold showers and I don't even need to moisturise after showers. My skin looks healthy and clear it is so surreal. This medication is not a ste
Welcome back to this week's newsflash 1. Vedolizumab, a medication used for ulcerative colitis, shows promise in treating chronic pouchitis as well. A new study found it to be effective in reducing ulcer count and inducing mucosal healing. Do you want to know [more](https://www.healio.com/news/gastr
I am interested in participating in a clinical trial. I am leaning towards the 3 mentioned in the title, though I would love to hear about any others that seem promising. I am hoping there will be phase 3 trials in my area some time in the first half of 2018 for ABT-494 and PF-04965842. Phase 3 for
About 80% of my body was covered when I went to the dermatologist, so he sent me to hospital for inpatient treatment for 5 days. I did a paraffin bath -> topical steroid -> wet wrap -> emollient treatment twice a day and everything has cleared up. I've been given a metric tonne of moisturiz
Almost a year ago, after years of worsening Atopic Dermatitis, i said enough is enough, and decided to buy Upadacitinib, a JAK inhibitor originally used for rheumatoid arthritis, after reading about very promising clinical trials for AD. When i posted about it many of you guys were surprised about
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
GUSELKUMAB is a Biologic (IL-23 Inhibitor), while UPADACITINIB belongs to the JAK Inhibitor class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles. GUSELKUMAB is administered via Subcutaneous or Intravenous, whereas UPADACITINIB uses Oral. Route of administration can affect onset of action and patient adherence.
GUSELKUMAB carries 4 FDA warnings. UPADACITINIB carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.