Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare IPILIMUMAB (YERVOY) and Nivolumab (Opdivo) — clinical data, side effects, and patient experiences.
YERVOY, Yervoy · Immune Checkpoint Inhibitor
How it works
12.1 Mechanism of Action CTLA-4 is a negative regulator of T-cell activity. Ipilimumab is a monoclonal antibody that binds to CTLA-4 and blocks the interaction of CTLA-4 with its l...
Approved for
Opdivo · Immune Checkpoint Inhibitor
How it works
PD-1 blocking monoclonal antibody that restores T-cell anti-tumor immune response.
Approved for
Estimated frequency (%) based on clinical trial data
Based on 17 Reddit discussions
IPILIMUMAB
44%
positive
9 threads
Nivolumab
63%
positive
8 threads
% of discussions mentioning each side effect
9 Reddit threads analysed for IPILIMUMAB
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
54 upvotes
Most discussed side effects in community
Last Updated: May 11, 2025 In order to advance research and acquire treatments, it is necessary we participate in clinical trials whenever possible. The faster these trials are completed, the faster we can get treatments. If you are able, please consider looking through this guide to find a trial th
Hello everyone: I am writing this post, I guess, because I wanted to share my experience with anyone who might have questions about melanoma from someone who’s been through almost everything modern treatment can throw at me. I’ve also done some peer support volunteering, and have experienced firstha
With the commitment of the [$30 million funding from Yorkville Advisors Global](https://www.cytodyn.com/newsroom/detail/649/cytodyn-secures-30-million-commitment-from-yorkville), CytoDyn continues to pursue its goals and ambitions, not just in ColoRectal Cancer, but in all its endeavors. Who signed
Oncotelic is an immuno-oncology company based out of California, with over 30 years of experience in their management team, they have dedicated themselves to developing the first in class RNA therapeutics as well as small molecule drugs against cancer and infectious diseases. A they have filed over
Hellllloooo From (thankfully not sunny) London 🌧️ So… I moved to London on 12th Jan for a fresh start New chapter. Big city energy. Maybe a bit of culture. Maybe a coffee that costs more than my first car. Juggling which job offer to take and which house to choose to get us out of the Airbnb. Inst
I've been posting here for a bit, so I thought I should share my story as well. I hope it helps someone in their journey. It's a super long one, because I love writing stories, and it's super easy when it was factual and I was present for all of it. If you want a TD;LR version, I had colon cancer. I
11/17/2018 - Copy of blog found at martinshkreli.com Biopharma/Investing ————————— Celgene deep-dive is progressing smoothly. I’ve skimmed hundreds of papers (4000 Revlimid entries in Pubmed), docket entries and more in preparation. Thanks for the crazy amount of mail. Fascinating, if not desperate,
Financials, Market Cap: 38.999M USD Current Price: 0.1100 USD 52 Week Range: 0.0800 - 0.2600 USD Average Volume: 228,763 (As of July 14th, 2022) ​ [https://ca.finance.yahoo.com/quote/OTLC?p=OTLC&.tsrc=fin-srch](https://ca.finance.yahoo.com/quote/OTLC?p=OTLC&.tsrc=fin-srch) &#x
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
8 Reddit threads analysed for Nivolumab
Overall Sentiment
Slightly positive
Comparison Threads
0
Avg Post Score
109 upvotes
Most discussed side effects in community
Thousands of patients will benefit from a new cancer jab for more than a dozen types of the disease, with the NHS the first in Europe to offer the new injection. The health service is rolling out an injectable form of immunotherapy, nivolumab, which means patients can receive their fortnightly or mo
Hey everyone. I know this update has taken longer than expected, but a lot has happened and I wanted to wait to post until now after an eventful month. First off, I would like to say that rapamycin really did save my life. I was about to give up when I tried it, and it was the miracle I needed to b
​ Given everything that’s going on with the movement against shorting, I present HTBX. \~25% avg daily short interest([https://fintel.io/ss/us/htbx](https://fintel.io/ss/us/htbx)), with a float of 21.75M shares. Forget about GME, AMC, NOK, etc. No institution should short a company that’s
Here’s my complete DD on my favorite play right now, HTBX. HTBX is a preclinical bio flush with cash. I’m going to give a basic background on the company, go over financials, go through the upcoming catalysts, include an expected value model on one of the drugs, and with all this seemingly good info
Background info Male, 35 years old, diagnosed 25th July 2025 Stage 4 Esophageal Cancer with liver mets Prognosis 12-16 months to live Current Treatment: Nivolumab and Folfox Intending to fight it and live for the next 60 years to die old toothless and in bed How many survivors out there that can rea
Hi everyone, I’m looking for advice or shared experiences. My husband is 31 years old and has stage 4 melanoma (BRAF negative) that has spread (including to bone). He is now bed bound, in significant pain, and confused at times (he had an episode of unresponsiveness recently). MRI, CT, EEG, X-rays a
A paper published in *Cancers*, a journal with a respectable impact factor (5.2), found that medical marijuana & immunotherapy was a potentially lethal combination (1). This manuscript, and a similar earlier one by the same lab (2), have been cited hundreds of times including by some clinical p
We have a patient coming up for CAR-T who is currently getting nivolumab and brentuximab. In my researching today, I found that T-cell lytic drugs should be held 8 weeks prior to collection and that immune targeted therapies should be held for "several half lives or 1 month". With the half life of n
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
Both IPILIMUMAB and Nivolumab belong to the Immune Checkpoint Inhibitor class. While they share a similar mechanism of action, differences in pharmacokinetics, dosing, and side effect profiles may make one more suitable than the other for individual patients.
IPILIMUMAB carries 4 FDA warnings. Nivolumab carries 2 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.