Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Compare Lisinopril (Zestril) and Losartan (Cozaar) — clinical data, side effects, and patient experiences.
Zestril, Prinivil · ACE Inhibitor
How it works
Inhibits angiotensin-converting enzyme (ACE), preventing conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, leading to decreased blood pressure and reduced al...
Approved for
Cozaar · ARB (Angiotensin II Receptor Blocker)
How it works
Selectively blocks the binding of angiotensin II to the AT1 receptor found in many tissues, reducing vasoconstriction, aldosterone secretion, and sympathetic activity.
Approved for
Estimated frequency (%) based on clinical trial data
Based on 30 Reddit discussions
Lisinopril
47%
positive
15 threads
Losartan
7%
positive
15 threads
% of discussions mentioning each side effect
15 Reddit threads analysed for Lisinopril
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
57 upvotes
Most discussed side effects in community
3 months after an initial 177/112 reading in the hospital and 168/109 reading at the doctors the next day. I have finally begun to hit below 120/80. Currently taking lisinopril 20mg and am hoping to be off it by September which is my next checkup. I swapped diets, went from never leaving the house t
Pretty much exactly two months after my hypertensive crisis that saw me in hospital. I'm very firmly in the normal range. Unfortunately, I've got a bit of kidney damage and my eyes had hemorrhages from undiagnosed diabetes along with this. Nothing that can't be managed. The 40mg lisinopril, 10 mg
I wanted to share my experience in case it helps someone who might be in the same confusing situation I was in. I’m a **46 year old male,** fairly active, healthy weight, and generally careful with my lifestyle. About a year and a half ago, I started paying closer attention to my blood pressure, whi
First, thanks to this sub for all the helpful information I've been able to take from all your posts. Grateful for this resource and practical experience from you all. This is my first post here, but wanted to share my story in hopes it might calm someone down who is starting their process. In early
Morning BP much better, two weeks in starting Valsartan, used to take lisinoprill, now on arb, 72 years old.
When doc wanted to double my meds in May (Lisinopril 10mg to 20mg), I lost it. I thought I was on track to drop meds but didn’t have the nerve to check my own pressure at home due to anxiety about the numbers. Lost 10 lbs, eating like a vegetarian, quit booze, started walking and meditating. Grant
A month an a half ago it was 150/92. Lisinopril 10mg worked for me
Just wanted to share my story of getting my BP under control as motivation for all of us who struggle with it. I am 46 yo, fit and athletic individual (155lbs, distance runner, scuba diver) who had a reasonably good diet and mild alcohol use. During a regular health checkup, my BP was very high and
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
15 Reddit threads analysed for Losartan
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
60 upvotes
Most discussed side effects in community
I’m a 32M and went almost my entire 20s not worrying about or even checking my blood pressure. When I was 30 I began having tachycardia episodes with high blood pressure readings which I had to go to ER for 3 times in a period of a few months with my readings at around 190/100 I got on losartan 100
Today went to see my cardiologist and no longer need to take losartan nor atorvastatin ! Got to a healthy weight and good diet that he said I no longer need the medication. Hopefully I can stay off it from now on. Im 5,8 went from 225lbs down to 185, eating a lot of food with high sodium to no/low
Hello all. I’ve been diagnosed with hypertension since 2021. I take losartan 12.5 mg 2x day, hydralazine 100mg 3x day , Carvedilol/coreg 25mg 2x day, amlodipine/norvasc 10mg 1x day (mornings), aspirin 324mg 1x day and a vitamin b12 as directed by my doctor. Yesterday I stood up and went into the kit
Hi, how is it going. Today I'm officially off blood pressure meds completely. With lifestyle changes, low sodium diet, low sugar, aerobic exercise and weight loss. I had blood pressure in the 170 to 180 systolic in January of 2025 after heart surgery on November 2024. I was 230 pounds and am current
I wanted to share with this group since I’ve gained so much value from this forum. Sometimes I think people don’t share their positive results enough, and it can really skew people’s ideas of what medicating hypertension will be like. I put off getting medicated for 15 years. My story was basically
I take 100 mg of Losartan daily, but before meds I was easily in the 140-150/90-100 range. Even after taking medication I was usually in the 130/90+ range. My resting heart rate used to sit at about 110 too. I felt like shit and my bod was so tense. But recently I stopped drinking and smoking and be
25M. When I was first diagnosed with hypertension (late 2022), I was hesitant to start any synthetic medication. I tried the “natural” route first — mainly beetroot juice. It did help a bit, but having to constantly buy, wash, cut, and juice beets was too time-consuming with my schedule as a univers
My blood pressure (seemingly) started giving me problems beginning of this year and I was put on losartan 50mg. I take that once a day and it seems to control my BP well (below 130/80). However, in the 4 months I've been on this medication, I've noticed when I'm on my period, my blood pressure shoot
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
Lisinopril is a ACE Inhibitor, while Losartan belongs to the ARB (Angiotensin II Receptor Blocker) class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles. Lisinopril has a half-life of 12 hours, compared to 2 hours (active metabolite: 6-9 hours) for Losartan. A longer half-life may allow for less frequent dosing but can also mean side effects persist longer.
Both medications are approved for Hypertension. When two drugs treat the same condition, the choice between them often depends on the patient's medical history, other medications, tolerability, and prescriber preference.
Lisinopril carries 2 FDA warnings. Losartan carries 1 FDA warning. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
There is 1 clinical study directly comparing Lisinopril and Losartan. Head-to-head trial data provides the strongest evidence for comparative effectiveness, though study design, endpoints, and patient populations should be considered when interpreting results.
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.