What is the difference between Lurasidone Hcl and Quetiapine Fumarate Er?

Lurasidone Hcl and Quetiapine Fumarate Er are both Atypical Antipsychotics, so they work through the same broad mechanism. They differ in dosing, half-life, side-effect frequency, and how individual patients tolerate them. See the head-to-head sections below for the specifics.

Can Lurasidone Hcl and Quetiapine Fumarate Er be used for the same conditions?

Both medications are prescribed for overlapping indications including See full prescribing information. Always verify with your prescriber and the current FDA label before switching.

Is Lurasidone HCL the same as Quetiapine Fumarate ER?

No. Lurasidone HCL (Lurasidone Hcl) and Quetiapine Fumarate ER (Quetiapine Fumarate Er) are distinct medications. They are sometimes confused because of similar branding or because they treat overlapping conditions, but they have different active ingredients and different safety profiles.

Which has fewer side effects, Lurasidone Hcl or Quetiapine Fumarate Er?

Side-effect frequency varies by individual. The side-effect comparison section on this page shows FAERS-reported events for each drug side by side. FAERS is voluntary reporting, so it reflects what patients and clinicians chose to report, not absolute population risk.

Can I switch from Lurasidone Hcl to Quetiapine Fumarate Er?

Switching medications should always be done under prescriber supervision. The "patient stories" section on this page includes accounts from people who have made the switch and what their transition felt like, but those are individual experiences, not protocols.

Lurasidone Hcl vs Quetiapine Fumarate Er

Compare Lurasidone Hcl (Lurasidone HCL) and Quetiapine Fumarate Er (Quetiapine Fumarate ER), clinical data, side effects, and patient experiences.

Lurasidone Hcl

Lurasidone HCL · Atypical Antipsychotic

How it works

Other agent

Approved for

See full prescribing information

OralTablet

Quetiapine Fumarate Er

Quetiapine Fumarate ER · Atypical Antipsychotic

How it works

Other agent

Approved for

however

diagnosis can be challenging. For pediatric schizophrenia

symptom profiles can be variable

and for bipolar I disorder

OralTablet

Quick Comparison

Lurasidone HclQuetiapine Fumarate Er

Drug Class

Atypical Antipsychotic

Route

Oral

Half-Life

N/A

FDA Approved

N/A

Side Effect Frequency Comparison

Estimated frequency (%) based on clinical trial data

Side Effects

Lurasidone Hcl

Drug Not Working

>10%

Anxiety

1-10%

Depression

1-10%

Weight Gain

1-10%

Drowsiness

1-10%

Nausea

1-10%

Insomnia

1-10%

Fatigue

1-10%

Quetiapine Fumarate Er

Drug Not Working

1-10%

Insomnia

1-10%

Fatigue

1-10%

Weight Gain

1-10%

Drowsiness

1-10%

Nausea

1-10%

Depression

1-10%

Anxiety

1-10%

FDA Warnings

Lurasidone Hcl

1 Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death
Analyses of 17 placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1
7-times the risk of death in placebo-treated patients
Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4

Quetiapine Fumarate Er

1 Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death
Analysis of 17 placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1
7 times the risk of death in placebo-treated patients
Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4

Clinical Trial Data

No head-to-head clinical studies found for Lurasidone Hcl vs Quetiapine Fumarate Er.

Lurasidone Hcl vs Quetiapine Fumarate Er: What You Should Know

Key Differences

Both Lurasidone Hcl and Quetiapine Fumarate Er belong to the Atypical Antipsychotic class. While they share a similar mechanism of action, differences in pharmacokinetics, dosing, and side effect profiles may make one more suitable than the other for individual patients.

Safety Considerations

Lurasidone Hcl carries 4 FDA warnings. Quetiapine Fumarate Er carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..

This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.

Related Comparisons

Olanzapine vs Quetiapine Fumarate Er→Quetiapine Fumarate Er vs Ziprasidone→Lurasidone Hydrochloride vs Quetiapine Fumarate Er→Paliperidone vs Quetiapine Fumarate Er→Aripiprazole vs Quetiapine Fumarate Er→Quetiapine Fumarate Er vs Risperidone→

Primary sources

Every figure on this comparison links back to its primary source. See data sources and methodology for the full provenance trail.

Lurasidone Hcl: DailyMed label · FAERS adverse events · ClinicalTrials.gov
Quetiapine Fumarate Er: DailyMed label · FAERS adverse events · ClinicalTrials.gov

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Lurasidone Hcl vs Quetiapine Fumarate Er

Compare Lurasidone Hcl (Lurasidone HCL) and Quetiapine Fumarate Er (Quetiapine Fumarate ER), clinical data, side effects, and patient experiences.

Lurasidone Hcl

Lurasidone HCL · Atypical Antipsychotic

How it works

Other agent

Approved for

See full prescribing information

OralTablet

Quetiapine Fumarate Er

Quetiapine Fumarate ER · Atypical Antipsychotic

How it works

Other agent

Approved for

however

diagnosis can be challenging. For pediatric schizophrenia

symptom profiles can be variable

and for bipolar I disorder

OralTablet

Quick Comparison

Lurasidone HclQuetiapine Fumarate Er

Drug Class

Atypical Antipsychotic

Route

Oral

Half-Life

N/A

FDA Approved

N/A

Side Effect Frequency Comparison

Estimated frequency (%) based on clinical trial data

Side Effects

Lurasidone Hcl

Drug Not Working

>10%

Anxiety

1-10%

Depression

1-10%

Weight Gain

1-10%

Drowsiness

1-10%

Nausea

1-10%

Insomnia

1-10%

Fatigue

1-10%

Quetiapine Fumarate Er

Drug Not Working

1-10%

Insomnia

1-10%

Fatigue

1-10%

Weight Gain

1-10%

Drowsiness

1-10%

Nausea

1-10%

Depression

1-10%

Anxiety

1-10%

FDA Warnings

Lurasidone Hcl

1 Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death
Analyses of 17 placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1
7-times the risk of death in placebo-treated patients
Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4

Quetiapine Fumarate Er

1 Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death
Analysis of 17 placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1
7 times the risk of death in placebo-treated patients
Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4

Clinical Trial Data

No head-to-head clinical studies found for Lurasidone Hcl vs Quetiapine Fumarate Er.

Lurasidone Hcl vs Quetiapine Fumarate Er: What You Should Know

Key Differences

Safety Considerations

This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.