Compare METHOTREXATE (METHOTREXATE) and PREDNISONE (PredniSONE) — clinical data, side effects, and patient experiences.
METHOTREXATE, Trexall, Otrexup · DMARD
How it works
12.1 Mechanism of Action Methotrexate inhibits dihydrofolic acid reductase. Dihydrofolates must be reduced to tetrahydrofolates by this enzyme before they can be utilized as carrie...
Approved for
PredniSONE, Deltasone, Rayos · Corticosteroid
How it works
Corticosteroid agent
Approved for
Estimated frequency (%) based on clinical trial data
Based on 30 Reddit discussions
METHOTREXATE
20%
positive
15 threads
PREDNISONE
20%
positive
15 threads
% of discussions mentioning each side effect
15 Reddit threads analysed for METHOTREXATE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
125 upvotes
Most discussed side effects in community
Edit #3: I passed out today on my apartment steps out of absolutely the worst pain I’ve ever had in my life and someone saw me and called an ambulance. I finally got a diagnosis in the emergency room after bawling my eyes out of frustration at this entire situation and they found out I have a corona
This is going to be so, so, so long and I’m so sorry. But we don’t know what else to do. I’ve tried to compress it the best I could. 3f with medical mystery. First year of life: -couldn’t latch until 2 months old -refused all food, in all forms. -up every 20 minutes every single night, wouldn’t
Hey /r/pharmacy I'm a mod over on the /r/lupus sub and we got our [first report](https://www.reddit.com/r/lupus/comments/vt9owi/denied_my_methotrexate/) from a from an established user of the sub saying their methotrexate prescription has been denied due to the recent overturning of roe. This has [b
I've been dancing my heart out for the last couple days. In public. I don't know why I'm just happy to be alive and moving and I don't even need music. It is honestly so abnormal for me to be dancing that I figured I should ask here? Nothing bad comes from the urge to dance in public yeah? F19 5'4 1
https://www.oscn.net/dockets/GetCaseInformation.aspx?db=oklahoma&number=CF-2023-2233&cmid=4194257 Maybe fuzzy on details, but basically this case was a doc who ordered mtx for a patient and sent the order as qd vs qw. Pharmacist filled it. Patient died. Obviously very sad, we just normally
F23 just ran a 10k. For reference I use to be a big runner so I have pride but haven't ran in a few months so no foundation. Absolutely killed myself to PR today. The race was brutal with cramping in my legs and lower back. I have probably ran hundreds of races. NEVER before have I gotten so immedi
25F USA 130 lbs 5'6 Meds: Prednisone, Cymbalta, 5mg Percocet 3x a day I will appreciate any insight. I'm so frustrated and exhausted I can hardly think straight by this point. Typing this from a hospital bed, actually! I will try to provide how this affects me both physically and mentally, and my st
Be careful and vigilant when dealing with maverick prescribers. Look at this example, the dosage was flagged and followed up on yet dispensed regardless. https://www.theage.com.au/national/victoria/drug-for-common-skin-disorder-implicated-in-grandfather-s-death-20180206-p4yzik.html
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
15 Reddit threads analysed for PREDNISONE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
527 upvotes
Most discussed side effects in community
Edit: I deleted the vaping post a while ago because doctors kept judging me for it. I’ve kept screenshots of it, they were moderators telling me NOT to go to the ER making me feel stupid. At eosinophil of 5800. So yeah. I’m not lying about the post I just deleted it because of anxiety before the hos
31F, don’t want to give too much identifying info since there aren’t that many bat rehabilitators in the world. No relevant PMH. I’m normally the one answering questions about rabies, not asking them, but this is more than I know and more than my doctor knows, so I’m hoping this might happen to be s
Hi everyone, 6 year old male. 43 pounds. 45 inches tall. Caucasian. Canada. No allergies. Medical conditions: asthma. Medications: Advair BID, and Ventolin PRN. Was prescribed Prednisone for a possible asthma exacerbation, and recieved one 20mL dose on Wednesday morning then went to school, and caug
I can't embed images here, so I made a pdf with all text, pictures, and labs. [https://www.scribd.com/document/511582218/askdocs-pdf?secret\_password=VqmaLuJA0tGw5bGE5xYp](https://www.scribd.com/document/511582218/askdocs-pdf?secret_password=VqmaLuJA0tGw5bGE5xYp) It will be much easier to read th
Hi everyone (throwaway account here), I need help on how to proceed with a meeting I am going to have with my staff pharmacist who got caught on camera stealing drugs at 5 different instances in the past 3 months. All drugs were non narcotic for personal use such as cochicine, nitrofurantoin, naprox
Yesterday, I had a prescriber send over 12 seperate prednisone rx's trying to do a taper. Today, I had a prescriber writing for the 2.4mg wegovy but to inject 0.5mg. I asked them if they instructed the patient on how to get 0.5mg out of a pen designed to inject 2.4mg and they said "no, why? did the
Before official corona virus news started trickling in, I recall a large number of people coming into the pharmacy for a few months with a terrible cough that wouldn’t go away. For the most part these were regulars I had known for years with no outstanding health problems. Now that I think back we w
Hello. Just got a message from pharmacy about norco for chronic pain in an elderly patient, “alternative requested, please add icd code, is patient seeing pain specialist.” I do appreciate the concern, however in this particular patient I believe it is warranted, (she has tried several other class
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
METHOTREXATE is a DMARD, while PREDNISONE belongs to the Corticosteroid class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles.
METHOTREXATE carries 4 FDA warnings. PREDNISONE carries 2 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.
Every figure on this comparison links back to its primary source. See data sources and methodology for the full provenance trail.