Compare UPADACITINIB (Rinvoq) and USTEKINUMAB (YESINTEK) — clinical data, side effects, and patient experiences.
Rinvoq · JAK Inhibitor
How it works
12.1 Mechanism of Action Upadacitinib is a Janus kinase (JAK) inhibitor. JAKs are intracellular enzymes which transmit signals arising from cytokine or growth factor-receptor inter...
Approved for
YESINTEK, Stelara · Biologic (IL-12/23 Inhibitor)
How it works
12.1 Mechanism of Action Ustekinumab products are human IgG1қ monoclonal antibodies that binds with specificity to the p40 protein subunit used by both the IL-12 and IL-23 cytokine...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 27 Reddit discussions
UPADACITINIB
64%
positive
14 threads
USTEKINUMAB
38%
positive
13 threads
% of discussions mentioning each side effect
14 Reddit threads analysed for UPADACITINIB
Overall Sentiment
Slightly positive
Comparison Threads
0
Avg Post Score
30 upvotes
Most discussed side effects in community
For context: for pretty much all of last year over 80% of my body was covered in eczema rash. It was so severe I couldn't use the shower and had to either take baths or wash myself in the sink. My scalp was constantly peeling and I was *always* itchy. While my skin would get better in summer, it was
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Hey everyone! I just wanted to provide some sort of update having been on Upadacitinib for just over a month. My eczema is gone and I no longer need to take cold showers and I don't even need to moisturise after showers. My skin looks healthy and clear it is so surreal. This medication is not a ste
Welcome back to this week's newsflash 1. Vedolizumab, a medication used for ulcerative colitis, shows promise in treating chronic pouchitis as well. A new study found it to be effective in reducing ulcer count and inducing mucosal healing. Do you want to know [more](https://www.healio.com/news/gastr
I am interested in participating in a clinical trial. I am leaning towards the 3 mentioned in the title, though I would love to hear about any others that seem promising. I am hoping there will be phase 3 trials in my area some time in the first half of 2018 for ABT-494 and PF-04965842. Phase 3 for
About 80% of my body was covered when I went to the dermatologist, so he sent me to hospital for inpatient treatment for 5 days. I did a paraffin bath -> topical steroid -> wet wrap -> emollient treatment twice a day and everything has cleared up. I've been given a metric tonne of moisturiz
Almost a year ago, after years of worsening Atopic Dermatitis, i said enough is enough, and decided to buy Upadacitinib, a JAK inhibitor originally used for rheumatoid arthritis, after reading about very promising clinical trials for AD. When i posted about it many of you guys were surprised about
Hi there, I wanted to share my experience with eczema and how, in the past 1.5 years, these drugs changed my life: **Growing up and coping:** I’ve had eczema since I was six years old. It started on my elbows, ankles, and on my thigh where I had operations as a child. Around 10 or 11, it spread. I t
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
13 Reddit threads analysed for USTEKINUMAB
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
9 upvotes
Most discussed side effects in community
Welcome back to this week's newsflash 1. Surgery for UC can be a major life change, but it is often a necessary step when medications fail. Understanding the adjustments to diet and daily life afterward is crucial for recovery and long-term well-being. This guide explores what patients can expect re
#The Effectiveness of Medications for Ulcerative Colitis *This post was last revised September 19, 2019.* Here I have compiled data on the effectiveness of medications used to treat ulcerative colitis, as compared to placebos or to other medications. ###Risk Ratios (RRs) All values here are shown as
Since eternacept started to wear off over the years my docs gave me the choice to switch to Ustekinumab. The 3 months injection rhythm sounds pretty unreal when coming from 3-day-interval Eternacept jabs, but well.. you could call it progress in medical science. I am now 3 weeks in after my first do
I wanted to follow-up on a previous post I made regarding starting Stelara. https://old.reddit.com/r/Psoriasis/comments/yjhr6z/plaque_psoriasis_after_a_covid_vaccine/ I have now be on Stelara for 7 months and it has nearly cleared my Psoriasis. I stopped applying Clobetasol some months ago and each
I’ve been on biologics for about a year now, i started in December 2024. About 45ml shot of Ustekinumab every 3 months as prescribed by my dermatologist. Problem is, it is losing its efficacy. Since August, every time it clears up about 70%, the same thing happens, it comes back worse even with topi
Phase 3 trials to commence. Possibly another biological option. http://www.medscape.com/viewarticle/878838
Sulforaphane Protects from T Cell–Mediated Autoimmune Disease by Inhibition of IL-23 and IL-12 in Dendritic Cells [https://www.jimmunol.org/content/192/8/3530](https://www.jimmunol.org/content/192/8/3530) **Ustekinumab,** sold under the brand name **Stelara** is a [monoclonal antibody](https://en.wi
Hi everyone, i went through a lot of derms(atleast) from hand eczeme to funghus .. it is everything but nothing helps… my newest diagnose is pustulare psoriasis.. I aplied Winxory for 2weeks where my hands got „fine“ and then it happend again. my derm wants to put me on Ustekinumab?? just wante
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
UPADACITINIB is a JAK Inhibitor, while USTEKINUMAB belongs to the Biologic (IL-12/23 Inhibitor) class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles. UPADACITINIB is administered via Oral, whereas USTEKINUMAB uses Subcutaneous or Intravenous. Route of administration can affect onset of action and patient adherence.
UPADACITINIB carries 4 FDA warnings. USTEKINUMAB carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.
Every figure on this comparison links back to its primary source. See data sources and methodology for the full provenance trail.