ABACAVIR AND LAMIVUDINE

Other

Brand names: Abacavir and Lamivudine

Oral

Mechanism of Action

12.1 Mechanism of Action Abacavir and lamivudine tablet is an antiretroviral agent with activity against HIV-1 [see Microbiology ( 12.4 )]. Mechanism of Action Abacavir: Abacavir is a carbocyclic synthetic nucleoside analogue. Abacavir is converted by cellular enzymes to the active metabolite, carbovir triphosphate (CBV-TP), an analogue of deoxyguanosine-5'-triphosphate (dGTP). CBV-TP inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. Lamivudine: Lamivudine is a synthetic nucleoside analogue. Intracellularly lamivudine is phosphorylated to its active 5'-triphosphate metabolite, lamivudine triphosphate (3TC-TP). The principal mode of action of 3TC-TP is inhibition of RT via DNA chain termination after incorporation of the nucleotide analogue.

Indications

1 INDICATIONS AND USAGE Abacavir and lamivudine tablet

a combination of abacavir and lamivudine

both nucleoside analogue HIV-1 reverse transcriptase inhibitors

is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection. ( 1 ) Abacavir and lamivudine tablets

in combination with other antiretroviral agents

are indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection.

Contraindications

• 4 CONTRAINDICATIONS Presence of HLA-B*5701 allele. ( 4 ) Prior hypersensitivity reaction to abacavir or lamivudine. ( 4 ) Moderate or severe hepatic impairment. ( 4

FDA Warnings

5 WARNINGS AND PRECAUTIONS Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues
1 Hypersensitivity Reactions Serious and sometimes fatal hypersensitivity reactions have occurred with abacavir, a component of abacavir and lamivudine tablets
Patients who carry the HLA-B*5701 allele are at a higher risk of abacavir hypersensitivity reactions; although, patients who do not carry the HLA-B*5701 allele have developed hypersensitivity reactions
Due to the potential for severe, serious, and possibly fatal hypersensitivity reactions with abacavir: All patients should be screened for the HLA-B*5701 allele prior to initiating therapy with abacavir and lamivudine tablets or reinitiation of therapy with abacavir and lamivudine tablets, unless patients have a previously documented HLA-B*5701 allele assessment

Known Side Effects

8 documented side effects by frequency

Anxiety

1-10%

Fever

1-10%

Nausea

1-10%

Fatigue

1-10%

Rash

1-10%

Headache

1-10%

Vomiting

1-10%

High Blood Pressure

0.1-1%

Community Discussions

2 Reddit threads analysed for ABACAVIR AND LAMIVUDINE

Overall Sentiment

Mixed

Comparison Threads

Avg Post Score

1 upvotes

Patient Experiences (r/pharmacy, r/AskDocs & more)

Abacavir Vs Lamivudine - Alerts, ADR and Dosing

r/TDPinfo104y ago

Abacavir Vs Lamivudine - Alerts, ADR and Dosing

r/u_MrStrider104y ago

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

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Formulations

Dosage Forms

Tablet

Route

Oral