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Brand names: Acetylcysteine
12.1 Mechanism of Action Acetylcysteine has been shown to reduce the extent of liver injury following acetaminophen overdose. Acetaminophen doses of 150 mg/kg or greater have been associated with hepatotoxicity. Acetylcysteine probably protects the liver by maintaining or restoring the glutathione levels, or by acting as an alternate substrate for conjugation with, and thus detoxification of, the reactive metabolite of acetaminophen.
11 documented side effects by frequency
15 Reddit threads analysed for ACETYLCYSTEINE
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Threads directly comparing ACETYLCYSTEINE to other medications
We all make mistakes, we’re all human. What’s scenario that sticks out for you? Could be you, or your “coworker” if no one wants to admit it. Interested to hear and learn from everyone in pharmacy. Would be helpful for students to learn from our mistakes I’ll start. I work in a hospital and my “cow
Hi all, I'm a male, 24 years old, 5ft9 and 75 kgs. I've searched all over Google but couldn't find a definitive answer. Was hoping one of you could clarify for me. Does nitroglycerin inhibit/induce the metabolism of other drugs, specifically diazepam? If so, how and which ones? As far as I found it
I'm 15, 170cm, 63 kg. male. I don't want to cause too much drama because things are strained as it is but I don't know how to solve this without making matters worse. I've had asthma since I was pretty little, so it's nothing new. My dad never liked it and felt it was a made up thing. Usually it's
First, some details about my dad... My dad is a 75 y/o norwegian (we live in north of Norway). He is about 173cm, about 98kg, doesn't drink, do drugs, nor smoke (at all). He's got a heart-failure that occasionally gives me breathing problems, especially during nights aka when he is sleeping. It is a
N-acetylcysteine is a modified form of the amino acid cysteine. Unlike cysteine, it is capable of crossing the blood-brain barrier. Historically it has most commonly been used in treating acetaminophen overdose. It is now being used in treating various psychiatric disorders and lung diseases. While
Doesn't N-acetylysteine not interfere with acetaminophen's therapeutic effects, since it just helps enhance metabolism of acetaminophen's toxic metabolite (NAPQI) after its been formed? That would make me think an acetaminophen product that also contains n-acetylcysteine would be just as effective
I've been working in a hospital for 8 years. In the past 6 months, I've seen 5 APAP overdoses wherein we've had to dose acetylcysteine IV. In the **7 years** before that, we saw \~9. Have you people seen any sort of uptick in cases like this? Also, opinions on whether the US should move to bliste
Hi everyone! I need to know the maximum daily dose of N-acetylcysteine, but I can't find it. Does anyone know? Thanks in advance! Edit: I should have mentioned, I was discussing with a college (I'm still in school!). No need to call poison control ahah Oral route, as adjuvant for obstructive lung di
Male, 30 years old, 5'9, 167lbs Having conducted only cursory research thus far, I am curious to learn if n-acetylcysteine can induce b9/b12 and possibly b6 deficiency. This is not a question regarding probability (but if you're especially keen to provide an assessment regarding the probability, p
I found [this](http://www.sciencedirect.com/science/article/pii/S1386634605004766) study which seems to show that NAC administered before alcohol prevents some of the liver toxicity, but administered afterwards it actually makes the damage more severe. My understanding is that the way it works to pr
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Dosage Forms
Tablet
Route
Intravenous