ADALIMUMAB-AATY

TNF Inhibitor

Brand names: Yuflyma

Oral

Mechanism of Action

12.1 Mechanism of Action Adalimumab products bind specifically to TNF-alpha and block its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab products also lyse surface TNF expressing cells in vitro in the presence of complement. Adalimumab products do not bind or inactivate lymphotoxin (TNF-beta). TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. Elevated concentrations of TNF are found in the synovial fluid of patients with RA, JIA, PsA, and AS and play an important role in both the pathologic inflammation and the joint destruction that are hallmarks of these diseases. Increased concentrations of TNF are also found in psoriasis plaques. In Ps, treatment with YUFLYMA may reduce the epidermal thickness and infiltration of inflammatory cells. The relationship between these pharmacodynamic activities and the mechanism(s) by which adalimumab products exert their clinical effects is unknown. Adalimumab products also modu

Indications

1 INDICATIONS AND USAGE YUFLYMA is a tumor necrosis factor (TNF) blocker indicated for: Reducing signs and symptoms

inducing major clinical response

inhibiting the progression of structural damage

posterior

and panuveitis in adults and pediatric patients 2 years of age and older. ( 1.9 ) 1.1 Rheumatoid Arthritis YUFLYMA is indicated for reducing signs and symptoms

Contraindications

• 4 CONTRAINDICATIONS None. None ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS Serious infections: Do not start YUFLYMA during an active infection
If an infection develops, monitor carefully, and stop YUFLYMA if infection becomes serious ( 5
2 ) Anaphylaxis or serious hypersensitivity reactions may occur ( 5
1 Serious Infections Patients treated with adalimumab products, including YUFLYMA, are at increased risk for developing serious infections involving various organ systems and sites that may lead to hospitalization or death

Known Side Effects

9 documented side effects by frequency

Drug Not Working

>10%

Fatigue

1-10%

Joint Pain

1-10%

Rash

1-10%

Condition Worsened

1-10%

Nausea

1-10%

Diarrhea

1-10%

Headache

1-10%

Hair Loss

1-10%

Community Discussions

2 Reddit threads analysed for ADALIMUMAB-AATY

Overall Sentiment

Mixed

Comparison Threads

Avg Post Score

3 upvotes

Patient Experiences (r/pharmacy, r/AskDocs & more)

Humira no longer covered by my insurance

Just received a letter that my company will no longer cover Humira and for my adult child UC and offered generic adalimumab aaty or adalimumab-adaz instead. When first diagnosed, my adult child went through 3 different drugs until we found the right match that finally gave her life back and another

r/UlcerativeColitis381y ago

Hello Everyone! My insurance recently switched me from Humira to Adalimumab-aaty, which is a biosimilar. When I was taking Humira I barely felt the injection, but the adalimumab injections REALLY hurt! Has anyone else had this experience?? Any tips?

r/ankylosingspondylitis3283mo ago

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

Compare With

11 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral