What are the most common side effects of ADALIMUMAB-BWWD?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for ADALIMUMAB-BWWD. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is ADALIMUMAB-BWWD the same as Hadlima?

Hadlima is a brand name for ADALIMUMAB-BWWD. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

ADALIMUMAB-BWWD

Q: What is ADALIMUMAB-BWWD used for?

ADALIMUMAB-BWWD (brand name Hadlima) is a TNF Inhibitor indicated for 1 INDICATIONS AND USAGE HADLIMA is a tumor necrosis factor (TNF) blocker indicated for • Reducing signs and symptoms, inducing major clinical response, inhibiting the progression of structural damage.

Q: How does ADALIMUMAB-BWWD work?

ADALIMUMAB-BWWD works through the following mechanism: 12.1 Mechanism of Action Adalimumab products bind specifically to TNF-alpha and block its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab products also lyse surface TNF expressing cells in vitro in the presence of complement. Adalimumab products do not bind or inactivate lymphotoxin (TNF-beta). TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. Elevated concentrations of TNF are found in the synovial fluid of patients with RA, JIA, PsA, and AS and play an important role in both the pathologic inflammation and the joint destruction that are hallmarks of these diseases. Increased concentrations of TNF are also found in psoriasis plaques. In Ps, treatment with HADLIMA may reduce the epidermal thickness and infiltration of inflammatory cells. The relationship between these pharmacodynamic activities and the mechanism(s) by which adalimumab products exert their clinical effects is unknown. Adalimumab products also modu.

TNF Inhibitor

Brand names: Hadlima

Subcutaneous

Mechanism of Action

12.1 Mechanism of Action Adalimumab products bind specifically to TNF-alpha and block its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab products also lyse surface TNF expressing cells in vitro in the presence of complement. Adalimumab products do not bind or inactivate lymphotoxin (TNF-beta). TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. Elevated concentrations of TNF are found in the synovial fluid of patients with RA, JIA, PsA, and AS and play an important role in both the pathologic inflammation and the joint destruction that are hallmarks of these diseases. Increased concentrations of TNF are also found in psoriasis plaques. In Ps, treatment with HADLIMA may reduce the epidermal thickness and infiltration of inflammatory cells. The relationship between these pharmacodynamic activities and the mechanism(s) by which adalimumab products exert their clinical effects is unknown. Adalimumab products also modu

Indications

1 INDICATIONS AND USAGE HADLIMA is a tumor necrosis factor (TNF) blocker indicated for • Reducing signs and symptoms

inducing major clinical response

inhibiting the progression of structural damage

posterior

and panuveitis in adult patients ( 1.9 ) . 1.1 Rheumatoid Arthritis HADLIMA is indicated for reducing signs and symptoms

Contraindications

• 4 CONTRAINDICATIONS None. None ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS • Serious infections: Do not start HADLIMA during an active infection
If an infection develops, monitor carefully, and stop HADLIMA if infection becomes serious ( 5
2 ) • Anaphylaxis or serious hypersensitivity reactions may occur ( 5
1 Serious Infections Patients treated with adalimumab products, including HADLIMA, are at increased risk for developing serious infections involving various organ systems and sites that may lead to hospitalization or death

Known Side Effects

8 documented side effects by frequency

Injection Site Pain

>10%

Drug Not Working

1-10%

Joint Pain

1-10%

Fatigue

1-10%

Diarrhea

1-10%

General Unwellness

1-10%

Nausea

0.1-1%

Headache

0.1-1%

Community Discussions

7 Reddit threads analysed for ADALIMUMAB-BWWD

Overall Sentiment

Mixed

Comparison Threads

Avg Post Score

26 upvotes

Most discussed side effects in community

Edema (2)

Weight Loss (1)

Itching (1)

Stomach Pain (1)

Patient Experiences (r/pharmacy, r/AskDocs & more)

Is Humira a dead drug?

I just had a follow up with my gastrointerologist and the majority of our conversation was about all or most insurances not covering Abbvie’s Humira. He told me Abbie has been preparing to stop servicing Humira for a few years now and with the patent expiring, this is the year they have done it.

r/CrohnsDisease11218311mo ago

RA and weight loss drugs

First, I would just love to say that I am so excited I found this. Newer to Reddit. But the amount of information that I have read in this has helped me tremendously. I was diagnosed a year and a half ago. Been through methotrexate and prednisone and unfortunately, I have been in a flareup for most

r/rheumatoid27346mo ago

Weight Loss

Edema

Recaptured Remission

I just wanted to share my recent experience with recapturing remisson if it helps. I had been in Hadlima induced remission for 11 months and experienced the worst flare of my life the week before I started my new job. I was bed bound three full days and continued to suffer an additional three week

r/ankylosingspondylitis1142mo ago

Edema

insurance stopped covering Humira, offered Hadlima - but apparently only the citrate version?

Hi all, I have been taking Humira auto-injector pen for Chron's and hidradentritis supprativa for several years now. i have had almost no issues. January this year, I received a letter that my insurance no longer covers Humira. my doctor said they would submit a prior authorization for me to try

r/CrohnsDisease871y ago

Itching

Burnt Out

Hello everyone. I was diagnosed almost a year ago. my flair ups have been reduced thanks to Hadlima, but I still experience frequent flair ups. I have a mostly desk job but I find myself in such incredible paid from looking down at paperwork I sometimes have to leave mid day. I was recently contacte

r/ankylosingspondylitis832y ago

Stomach Pain

Ontario, Canada Experience - Hadlima

Just an informative post for those in Canada, but more specifically Ontario. My dermatologist, when I first met with her regarding HS, put me on an oral antibiotic (Amoxycilin) and a topical (clindamycin). Personally, the topical did not work for me, but after a few months, she recommended I try a

r/Hidradenitis833y ago

Any ex or current junkies on hadlima?

I'm an ex-junkie (8 years clean this past december) and I started hadlima a few months ago and I swear to God, for like 2-3 days after I take my shot, I feel vaguely like I'm going through withdrawal like sweaty, a little manic, jittery, rapid temperature shifts, and just like my whole body feels of

r/CrohnsDisease833mo ago

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → ADALIMUMAB-BWWD openFDA label JSON → ADALIMUMAB-BWWD FAERS adverse-event reports → ADALIMUMAB-BWWD ClinicalTrials.gov → completed Phase 2+ trials of ADALIMUMAB-BWWD

Compare With

11 available comparisons

Formulations

Dosage Forms

Tablet

Route

Subcutaneous