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DrugNote

ADQUEY

Other

Brand names: Difamilast

Topical

Mechanism of Action

12.1 Mechanism of Action Difamilast is an inhibitor of phosphodiesterase-4 (PDE-4). Difamilast’s inhibition of PDE-4 (a major cyclic adenosine monophosphate (AMP)-metabolizing enzyme) activity leads to accumulation of intracellular cyclic AMP and decreased productions of various cytokines and chemokines. However, the specific mechanism(s) by which difamilast exerts its therapeutic action is not well defined.

Indications

See full prescribing information

Contraindications

  • • 4 CONTRAINDICATIONS None. None. (4)

Known Side Effects

1 documented side effects by frequency

Itching
>10%

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Formulations

Dosage Forms

Tablet

Route

Topical