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Brand names: Binosto, Fosamax, FOSAMAX PLUS D
12.1 Mechanism of Action Animal studies have indicated the following mode of action. At the cellular level, alendronate shows preferential localization to sites of bone resorption, specifically under osteoclasts. The osteoclasts adhere normally to the bone surface but lack the ruffled border that is indicative of active resorption. Alendronate does not interfere with osteoclast recruitment or attachment, but it does inhibit osteoclast activity. Studies in mice on the localization of radioactive [ 3 H]alendronate in bone showed about 10-fold higher uptake on osteoclast surfaces than on osteoblast surfaces. Bones examined 6 and 49 days after [ 3 H]alendronate administration in rats and mice, respectively, showed that normal bone was formed on top of the alendronate, which was incorporated inside the matrix. While incorporated in bone matrix, alendronate is not pharmacologically active. Thus, alendronate must be continuously administered to suppress osteoclasts on newly formed resorption
Contraindications
6 documented side effects by frequency
7 Reddit threads analysed for ALENDRONATE SODIUM
Overall Sentiment
Mixed
Comparison Threads
4
Avg Post Score
2 upvotes
Most discussed side effects in community
Threads directly comparing ALENDRONATE SODIUM to other medications
Age: 60 * Sex: Male * Height: 5' 6'' * Weight- 190 pounds * Race: White * Duration of complaint: 10 months * Location (Geographic and on body) Northwestern United States, symptom is on left thumbnail * Any existing relevant medical issues: Diabetic (T1 / A1C-6.6), High Blood Pressure, High Choleste
My mother who is 73 years of age had dark brown colored urine for about 12 hours for the first time in her life about 10 days ago, then the color returned to normal without other apparent symptoms the next day. She has kidney stones (uric acid stone in one kidney and calcium oxalate in the other)
First some info per subreddit rules, then I'll describe the problem. I'm a white female, 63 years, 5'4", 122 lbs. I've had acid reflux for about 18 years. I take prescription Omeprazole. I take over the counter cimetidine as needed. I was recently diagnosed with hypothyroid and a vitamin D deficienc
So my mom's 59 now and her doctor told her that she's experiencing lower bone density (not necessarily osteoporosis yet). Or maybe she already has it? Not sure though because she's still doing a lot of stuff and going to the gym (albeit for cardio stuff like on the treadmill or doing Zumba). I'll s
Hi Everyone, I wanted to ask you about my mother. I apologize if it’s a long post, but I want to be as thorough as possible. My mom is 60 years old, is 5’5” and currently weights around 118 pounds. She has been healthy for most her life, with the exception of having gallstones in her gallbladder for
TLDR: I want to ask about a UTI condition for my mother, who is 73 years old. She has received multiple rounds of different antibiotics in a month, while bacteria count is down, her white blood cell and red blood cell counts stay elevated with blood detected in the urine. Would like to know if sh
I recently had blood work and my Vitamin D was 79. The results say 80 may be toxic. My doc on patient portal just said take less Vitamin D, however, I take NO Vitamin D except that found in a one-a-day multi supplement. My calcium is fine. Only other issue, was just diagnosed with osteoporosis
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3 available comparisons
Dosage Forms
Tablet
Route
Oral