ALFUZOSIN HYDROCHLORIDE

Alpha Blocker

Brand names: Alfuzosin Hydrochloride

Oral

Mechanism of Action

12.1 Mechanism of Action Alfuzosin is a selective antagonist of post-synaptic alpha 1 -adrenoreceptors, which are located in the prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra.

Indications

1 INDICATIONS AND USAGE Alfuzosin hydrochloride extended-release tablets

USP are indicated for the treatment of signs and symptoms of benign prostatic hyperplasia. Alfuzosin hydrochloride extended-release tablet is an alpha adrenergic antagonist

8.4

12.3 ) 1.1 Important Limitations of Use Alfuzosin hydrochloride extended-release tablets

USP are not indicated for the treatment of hypertension. Alfuzosin hydrochloride extended-release tablets

USP are not indicated for use in the pediatric population.

Contraindications

• 4 CONTRAINDICATIONS Alfuzosin hydrochloride extended-release tablets are contraindicated for use: in patients with moderate or severe hepatic impairment (Childs-Pugh categories B and C)
• since alfuzosin blood levels are increased in these patients [ see Use in Specific Populations ( 8.7 ) and Clinical Pharmacology ( 12.3) ]. with potent CYP3A4 inhibitors such as ketoconazole
• itraconazole
• and ritonavir
• since alfuzosin blood levels are increased [ see Drug Interactions ( 7.1 ) and Clinical Pharmacology ( 12.3 ) ]. in patients with known hypersensitivity

FDA Warnings

5 WARNINGS AND PRECAUTIONS Postural hypotension/syncope: Care should be taken in patients with symptomatic hypotension or who have had a hypotensive response to other medications or are concomitantly treated with antihypertensive medication or nitrates ( 5
There may be an increased risk of hypotension/postural hypotension and syncope when taking alfuzosin hydrochloride extended-release tablets concomitantly with anti-hypertensive medication and nitrates
3 Patients with Hepatic Impairment Alfuzosin hydrochloride extended-release tablets are contraindicated for use in patients with moderate or severe hepatic impairment [ see Contraindications ( 4 ), Use in Specific Populations ( 8
4 Drug-Drug Interactions Potent CYP3A4 Inhibitors Alfuzosin hydrochloride extended-release tablets are contraindicated for use with potent CYP3A4 inhibitors (e

Known Side Effects

11 documented side effects by frequency

Dizziness

>10%

Drug Not Working

>10%

Fatigue

1-10%

Shortness of Breath

1-10%

Weakness

1-10%

Diarrhea

1-10%

Falls

1-10%

Nausea

1-10%

Low Blood Pressure

1-10%

Headache

1-10%

General Unwellness

0.1-1%

Community Discussions

2 Reddit threads analysed for ALFUZOSIN HYDROCHLORIDE

Overall Sentiment

Mixed

Comparison Threads

Avg Post Score

202 upvotes

Most discussed side effects in community

Constipation (1)

Anxiety (1)

Sexual Dysfunction (1)

Abdominal Pain (1)

Patient Experiences (r/pharmacy, r/AskDocs & more)

NEW? START HERE! Prostatitis 101/Checklist + Sub Rules

**»** ***QUICK START! «*** 1. [SUCCESS STORIES in this subreddit](https://www.reddit.com/r/Prostatitis/comments/qwjj6j/reminder_simply_type_in_flairsuccess_story_at_the/?utm_source=share&utm_medium=web2x&context=3) 2. [TOP TIPS AND INFO (All Posts)](https://www.reddit.com/r/Prostatitis/comme

r/Prostatitis403223y ago

Constipation

Anxiety

Sexual Dysfunction

27M persistent burning at the urethra after prostatitis with no apparent explanation

Hello, I am a 27 years old, male, 168cm, 63kgs, white, currently living in Sweden. it is been almost an year since my gp diagnosed me with a mild case of prostatitis and prescribed me with antibiotics, that got the prostate to almost its previous size, but left me with a varying burning sensation t

r/AskDocs133y ago

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

Compare With

6 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral