ALISKIREN HEMIFUMARATE

Other

Brand names: Tekturna

Oral

Mechanism of Action

12.1 Mechanism of Action Renin is secreted by the kidney in response to decreases in blood volume and renal perfusion. Renin cleaves angiotensinogen to form the inactive decapeptide angiotensin I (Ang I). Ang I is converted to the active octapeptide angiotensin II (Ang II) by ACE and non-ACE pathways. Ang II is a powerful vasoconstrictor and leads to the release of catecholamines from the adrenal medulla and prejunctional nerve endings. It also promotes aldosterone secretion and sodium reabsorption. Together, these effects increase blood pressure. Ang II also inhibits renin release, thus providing a negative feedback to the system. This cycle, from renin through angiotensin to aldosterone and its associated negative feedback loop, is known as the renin-angiotensin-aldosterone system (RAAS). Aliskiren is a direct renin inhibitor, decreasing plasma renin activity (PRA) and inhibiting the conversion of angiotensinogen to Ang I. Whether aliskiren affects other RAAS components, e.g., ACE or

Indications

1 INDICATIONS AND USAGE Tekturna is a renin inhibitor (RI) indicated for the treatment of hypertension in adults and in pediatric patients weighing 50 kg or greater who are at least 6 years of age

to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events

including

as appropriate

lipid control

diabetes management

FDA Warnings

5 WARNINGS AND PRECAUTIONS Avoid concomitant use with ARBs or ACEIs particularly in patients with renal impairment [creatinine clearance (CrCl) <60 mL/min]
1 Fetal Toxicity Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death
Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death
2 Renal Impairment/Hyperkalemia/Hypotension when Tekturna is Given in Combination with ARBs or ACEIs Tekturna is contraindicated in patients with diabetes who are receiving ARBs or ACEIs because of the increased risk of renal impairment, hyperkalemia, and hypotension

Known Side Effects

14 documented side effects by frequency

Nausea

1-10%

High Blood Pressure

1-10%

Headache

1-10%

Fatigue

1-10%

Falls

1-10%

Weakness

1-10%

Dizziness

1-10%

Shortness of Breath

1-10%

Cough

1-10%

General Unwellness

1-10%

Diarrhea

1-10%

Vomiting

1-10%

Fever

1-10%

Drug Not Working

0.1-1%

Community Discussions

3 Reddit threads analysed for ALISKIREN HEMIFUMARATE

Overall Sentiment

Mixed

Comparison Threads

Avg Post Score

27 upvotes

Most discussed side effects in community

Dizziness (2)

Fatigue (2)

Weight Loss (1)

Headache (1)

Anxiety (1)

Peripheral Edema (1)

Patient Experiences (r/pharmacy, r/AskDocs & more)

In India over 2,644 died during clinical trial of drugs in 7 years: 'Clinical trial of two drugs - Bayer's Rivaroxaban a…

r/worldnews612013y ago

So.... as a retired senior with controlled high BP I'd like to contribute my story in the hope it may help someone with similar side effect issues. This is going to be long. Was diagnosed a long time ago with High BP which started slowly climbing as I aged. I honestly can't recall any of the 5 BP p

r/bloodpressure1862y ago

Dizziness

Fatigue

Weight Loss

Lisinopril: The Essential Guide for Hypertension Management

Close-up of a Lisinopril prescription bottle beside a blood pressure monitor and stethoscope on a bright medical desk. # Understanding Lisinopril: An ACE Inhibitor for Hypertension Treatment Lisinopril, commonly known by its brand name *Prinivil*, is a widely prescribed medication classified as

r/Healthylivingideas201y ago

Headache

Dizziness

Fatigue

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

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Formulations

Dosage Forms

Tablet

Route

Oral