Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Brand names: Alogliptin, Nesina, OSENI
12.1 Mechanism of Action Increased concentrations of the incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are released into the bloodstream from the small intestine in response to meals. These hormones cause insulin release from the pancreatic beta cells in a glucose-dependent manner but are inactivated by the dipeptidyl peptidase-4 (DPP-4) enzyme within minutes. GLP-1 also lowers glucagon secretion from pancreatic alpha cells, reducing hepatic glucose production. In patients with type 2 diabetes, concentrations of GLP-1 are reduced but the insulin response to GLP-1 is preserved. Alogliptin is a DPP-4 inhibitor that slows the inactivation of the incretin hormones, thereby increasing their bloodstream concentrations and reducing fasting and postprandial glucose concentrations in a glucose-dependent manner in patients with type 2 diabetes mellitus. Alogliptin selectively binds to and inhibits DPP-4 but not DPP-8 or DPP-9 act
Contraindications
11 documented side effects by frequency
15 Reddit threads analysed for ALOGLIPTIN
Overall Sentiment
Mixed
Comparison Threads
10
Avg Post Score
3 upvotes
Most discussed side effects in community
Threads directly comparing ALOGLIPTIN to other medications
I was going to start Ozempic tonight, but I just can't. I went looking to see if there were any tips or tricks to avoid nausea or to get a better idea of how long it lasts and saw that diabetic retinopathy IS an actual (though rare) side effect that might not go away. And you just don't know how muc
I'll probably cross post this to diabetes and endocrinology forums. Thanks for setting up an evidence based endocrine forum, I'll try to contribute. I did some work on the available data on CV outcome trials to date. This is a wordy summary of available trials, but hopefully shed some light on the p
So I'm being treated by the NHS as though I have type 2 diabetes. I also have a mitochondrial mutation that causes Maternally Inherited Diabetes and Deafness, but for the purposes of treatment I am T2. I'm a moderately overweight (not obese) reasonably active woman in my early 30's who also has PCOS
Hello everyone, i was diagnosed with type 2 diabetes earlier this year. I have experienced a blood sugar drop before in my life on a few different occasions. However, i started suffering from severe panick attacks after my mom passed away. I had a massive panick attack at work one day that was Trigg
https://preview.redd.it/qgzt1cr5508g1.png?width=1262&format=png&auto=webp&s=1d7e6e058d08fc996296ea562775720522ff54d4 [https://diabetesjournals.org/care/article/48/Supplement\_1/S181/157569/9-Pharmacologic-Approaches-to-Glycemic-Treatment](https://diabetesjournals.org/care/article/48/Supp
I have been taking Toujeo for about 5 years now and take it every night along witg alogliptin I am taking 65 units a night of Toujeo and Still i tested at 10.7 on my A1C this last time around. Truth be told I hadn't been checking my levels the last 4 months and probably have been eating out far too
I take Metformin, Alogliptin, and Empagliflozin. Before that I was taking Pioglitazone instead of Empagliflozin. My blood sugar was fantastic. My morning blood sugar was around 97mg to 115mg even after a hefty meal night before and the A1C was 6.5. Then the VA changed Pioglitazone to Empagliflozin b
Hey, I’m hoping someone may be able to help, Im 35F, 5ft 7in, roughly 9st 11lbs. Diagnosed with type 2 diabetes, anxiety, depression, high blood pressure, high fast rate, 2 previous occurrences of pulmonary embolism. Currently taking apixaban, losartan, Alogliptin, venlafaxine, amitriptyline and pro
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
20 available comparisons
Dosage Forms
Tablet
Route
Oral