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Brand names: Amlodipine and Valsartan
12.1 Mechanism of Action Amlodipine Amlodipine is a dihydropyridine calcium channel blocker that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Experimental data suggest that amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Negative inotropic effects can be detected in vitro but such effects have not been seen in intact animals at therapeutic doses. Serum calcium concentration is not affected by amlodipine. Within the physiologic pH range, amlodipine is an ionized compound (pKa=8.6), and its kinetic interaction with the calcium channel receptor is characterized by a gradual
Contraindications
12 documented side effects by frequency
13 Reddit threads analysed for AMLODIPINE AND VALSARTAN
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
4 upvotes
Most discussed side effects in community
I posted this to /r/ems the other day, but it's still on my mind. The EKGs in particular seem to be one of those where you ask 5 people for their opinion and get 6 different responses, so I'd love to hear your thoughts/comments. Dispatched to urgent care facility for shortness of breath. Arrive on s
36m 5'10" 262lbs who was diagnosed with ccRCC (Clear Cell Renal Cell Carcinoma) at 34 years old after suddenly having a series of Grand Mal seizures at which point I was transported to the ER by ambulance. Had additional seizures en route and at the hospital. Once the doctors were able to stop the
As stated, I am a 61F, 5'3" and 168 pounds with some periodic loss of function in my left hand and forearm with a pins and needles feeling. Been slowly getting worse over the last couple of years and just lately I'm losing feeling and its hard to drive and hold books, ipad, etc for more than a few
I am a 62-yo white female. Everything was fine last night and then I woke with blurry vision that glasses, time, and artificial tears have not cleared up. I can read if everything is greatly magnified, but everything is super blurry. Due to my complex history, I'm never sure which physician is the r
I was issuing a lot of Exforge HCT (amlodipine/valsartan/hctz) before the big valsartan recall. I only know of one other triple combo like it which is Tribenzor (amlodipine/olmesartan/hctz). I am not the biggest fan of olmesartan due to the rare occurrence of a Sprue like diarrhea. Are there any oth
28f. 5'5". 190lb. mixed white/asian. zoloft, amlodipine, hctz, valsartan (depression/anxiety, hypertension) drink heavily (alcoholic), no smoking, take 0.5mg xanax daily. for over the past 3-ish weeks, ive been craving the smell of cat litter, specifically urine clumped cat litter, like i literally
I was put on 5mg Amlodipine besylate (Norvasc) about a month ago to pair with my 160mg Valsartan for blood pressure. Two or three weeks ago, I was in my truck at work and almost fainted. My arms got numb, tunnel vision, rapid heart beat. This past Sunday, I was admitted to the ER because I felt the
male, 42, 5'11", 195 lbs, not a smoker, sleep apnea, fatty liver, medications below Got into "biohacking" supplement consumption and gradually started taking a ton of different things based on my own research or blogs. I have fatty liver but lately my ALT levels have gone through the roof without
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13 available comparisons
Dosage Forms
Tablet
Route
Oral