Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Brand names: BAVENCIO
12.1 Mechanism of Action PD-L1 may be expressed on tumor cells and tumor-infiltrating immune cells and can contribute to the inhibition of the anti-tumor immune response in the tumor microenvironment. Binding of PD-L1 to the PD-1 and B7.1 receptors found on T cells and antigen presenting cells suppresses cytotoxic T-cell activity, T-cell proliferation, and cytokine production. Avelumab binds PD-L1 and blocks the interaction between PD-L1 and its receptors PD-1 and B7.1. This interaction releases the inhibitory effects of PD-L1 on the immune response resulting in the restoration of immune responses, including anti-tumor immune responses. Avelumab has also been shown to induce antibody-dependent cell-mediated cytotoxicity (ADCC) in vitro. In syngeneic mouse tumor models, blocking PD-L1 activity resulted in decreased tumor growth.
Contraindications
7 documented side effects by frequency
4 Reddit threads analysed for AVELUMAB
Overall Sentiment
Slightly positive
Comparison Threads
1
Avg Post Score
72 upvotes
Most discussed side effects in community
Threads directly comparing AVELUMAB to other medications
Hey everyone! To give some context, I'm a registered nurse in Texas pursuing my MSN and, subsequently, Ph.D. I'm still trying to figure things out, but I'm interested in the research aspects of nursing and want to contribute to my field. As I go through the literature, mainly through the Emergency N
Hi, I’m [Dr. Due Diligence](https://linktr.ee/doctorduediligence), and I’m starting a weekly series where I am looking at the top shorted biotech stocks in the world to try and find value. I have worked in the clinic, academia, and for biotech startups before switching to investing full time. My inv
#**$KURA – Kura Oncology** **Overview:** Kura Oncology was created in 2007 and is based in California. The company is utilizing the genomic revolution to transform how cancer is treated, understanding that a patient’s response to treatment depends partially on the cancer’s genetic makeup. With an
I get a lot of messages asking about my cancer, so before I get to my story: I highly recommend visiting [BCAN.org](http://BCAN.org) and asking to be paired up in their survivor to survivor program. Every diagnosis is different and the survivor to survivor program pairs you with someone with simila
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
5 available comparisons
Dosage Forms
Tablet
Route
Intravenous