BENDAMUSTINE HYDROCHLORIDE

Electrolyte / Mineral

Brand names: Bendamustine Hydrochloride

Intravenous

Mechanism of Action

12.1 Mechanism of Action Bendamustine is a bifunctional mechlorethamine derivative containing a purine-like benzimidazole ring. Mechlorethamine and its derivatives form electrophilic alkyl groups. These groups form covalent bonds with electron-rich nucleophilic moieties, resulting in interstrand DNA crosslinks. The bifunctional covalent linkage can lead to cell death via several pathways. Bendamustine is active against both quiescent and dividing cells. The exact mechanism of action of bendamustine remains unknown.

Indications

See full prescribing information

Contraindications

• 4 CONTRAINDICATIONS Bendamustine hydrochloride injection is contraindicated in patients with a known hypersensitivity (e.g.
• anaphylactic and anaphylactoid reactions) to bendamustine
• polyethylene glycol 400
• absolute ethanol
• polyethylene glycol 400

FDA Warnings

5 WARNINGS AND PRECAUTIONS Myelosuppression: Delay or reduce dose and restart treatment based on ANC and platelet count recovery
4 ) Tumor Lysis Syndrome: May lead to acute renal failure and death; anticipate and use supportive measures in patients at high risk
Cases of SJS, DRESS and TEN, some fatal, have been reported
Advise females of reproductive potential and males with female partners of reproductive potential of the potential risk to a fetus and to use an effective method of contraception

Known Side Effects

5 documented side effects by frequency

Fever

1-10%

Drug Not Working

1-10%

Rash

0.1-1%

Diarrhea

0.1-1%

Nausea

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Intravenous