BRIVARACETAM INJECTION

Anticonvulsant

Brand names: Brivaracetam

Intravenous

Mechanism of Action

12.1 Mechanism of Action The precise mechanism by which brivaracetam exerts its anticonvulsant activity is not known. Brivaracetam displays a high and selective affinity for synaptic vesicle protein 2A (SV2A) in the brain, which may contribute to the anticonvulsant effect.

Indications

See full prescribing information

FDA Warnings

5 WARNINGS AND PRECAUTIONS Suicidal Behavior and Ideation : Monitor patients for suicidal behavior and ideation
4 ) Serious Dermatologic Reactions : Discontinue Brivaracetam unless an alternative etiology is established ( 5
1 Suicidal Behavior and Ideation Antiepileptic drugs (AEDs), including Brivaracetam , increase the risk of suicidal thoughts or behavior in patients taking these drugs for any indication
Pooled analyses of 199 placebo-controlled clinical trials (mono- and adjunctive therapy) of 11 different AEDs showed that patients randomized to one of the AEDs had approximately twice the risk (adjusted Relative Risk 1

Known Side Effects

6 documented side effects by frequency

Drug Not Working

1-10%

Fatigue

1-10%

Drowsiness

0.1-1%

Dizziness

0.1-1%

Falls

0.1-1%

Headache

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Intravenous