CALCITONIN SALMON

Other

Brand names: calcitonin salmon

Intramuscular, Subcutaneous

Mechanism of Action

12.1 Mechanism of Action Calcitonin salmon is a calcitonin receptor agonist. Calcitonin salmon acts primarily on bone, but direct renal effects and actions on the gastrointestinal tract are also recognized. Calcitonin salmon appears to have actions essentially identical to calcitonins of mammalian origin, but its potency per mg is greater and it has a longer duration of action. The actions of calcitonin on bone and its role in normal human bone physiology are still not completely elucidated, although calcitonin receptors have been discovered in osteoclasts and osteoblasts.

Indications

1 INDICATIONS AND USAGE Calcitonin salmon synthetic injection is a calcitonin

the need for continued therapy should be re-evaluated on a periodic basis. ( 1.4

along with other appropriate agents

when a rapid decrease in serum calcium is required

until more specific treatment of the underlying disease can be accomplished. It may also be added to existing therapeutic regimens for hypercalcemia such as intravenous fluids and furosemide

oral phosphate or corticosteroids

Contraindications

• 4 CONTRAINDICATIONS Hypersensitivity to calcitonin salmon or any of the excipients. Reactions have included anaphylaxis with death
• bronchospasm
• and swelling of the tongue or throat [see Warnings and Precautions (5.1) ] . Hypersensitivity to calcitonin salmon or any of the excipients. ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS Serious hypersensitivity reactions, including reports of fatal anaphylaxis have been reported
2 ) Malignancy: A meta-analysis of 21 clinical trials suggests an increased risk of overall malignancies in calcitonin salmon-treated patients
1 Hypersensitivity Reactions Serious hypersensitivity reactions have been reported in patients receiving calcitonin salmon injection, e
, bronchospasm, swelling of the tongue or throat, anaphylactic shock, and death due to anaphylaxis

Known Side Effects

14 documented side effects by frequency

Nausea

1-10%

Drug Not Working

1-10%

Falls

1-10%

Joint Pain

1-10%

Dizziness

1-10%

Headache

1-10%

Back Pain

1-10%

Shortness of Breath

1-10%

Weakness

1-10%

Fatigue

1-10%

Limb Pain

1-10%

Diarrhea

1-10%

Vomiting

1-10%

Weight Loss

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Intramuscular, Subcutaneous