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Brand names: INVOKANA, Invokana
12.1 Mechanism of Action SGLT2, expressed in the proximal renal tubules, is responsible for the majority of the reabsorption of filtered glucose from the tubular lumen. Canagliflozin is an inhibitor of SGLT2. By inhibiting SGLT2, canagliflozin reduces reabsorption of filtered glucose and lowers the renal threshold for glucose (RT G ), and thereby increases urinary glucose excretion (UGE). Canagliflozin increases the delivery of sodium to the distal tubule by blocking SGLT2-dependent glucose and sodium reabsorption. This is believed to increase tubuloglomerular feedback and reduce intraglomerular pressure.
Contraindications
5 documented side effects by frequency
11 Reddit threads analysed for CANAGLIFLOZIN
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
9 upvotes
Most discussed side effects in community
I’m just so happy i had to share somewhere. I had my test a couple days ago and got the results, been dreading but it turned out great! The medication (canagliflozin), brown rice and food control has been working the past 2 years. I know i’ll have to continue these for the rest of my life, but know
We went out to the ADA Expo in LA a couple weeks ago and wanted to share some interesting stuff we learned from a seminar on Current and Future Treatments on Diabetes [A few photos] (http://imgur.com/a/pMkDl) [SGLT-2] (http://www.forbes.com/sites/larryhusten/2013/03/29/fda-approves-first-sglt2-inh
So I am a type 2 diabetic taking Invokamet (Metformin+Canagliflozin). I like to have a drink or two with dinner here and there. ive notied though, that if I am drinking beer I get nauseous 2-3 hours after, but not after wine or liquor. Has anyone else seen side effects such as this?
I'm male, age 47, 5 foot 8, weigh about 250 pounds. Ever since going on insulin two years ago I've had a hell of a time losing weight. I also have degenerative disc disease and osteoarthritis of the spine which makes exercising difficult, but I am walking for 15 minutes every day after work, and wor
I'm wondering if anyone has started this med and could tell me how they feel about it. I'm a type 1 and it was offered to me to help lose weight. I'm just unsure of how it will change my BG, if I'll be having lots of hypos and if it really will help me lose weight. Any input would be great to hear.
I've been using Xigduo (metformin with canagliflozin) and I notice that when you eat spicy the capsaicin gets excreted through the urine as well. As a man you will end up with a spicy weiner when you pee. I am an extremely spicy eater but I thought I'd share this uncomfortable side effect for all of
https://preview.redd.it/haphqq6tm0rf1.png?width=3363&format=png&auto=webp&s=f200f3e9b7e0fb319c5fdd2a7f5ee9f1c364b214
[https://www.mdmag.com/medical-news/podcast-canagliflozin-approval-sglt2-inhibitors-bakris](https://www.mdmag.com/medical-news/podcast-canagliflozin-approval-sglt2-inhibitors-bakris)
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
19 available comparisons
Dosage Forms
Tablet
Route
Oral