CANDESARTAN CILEXETIL

Other

Brand names: CANDESARTAN CILEXETIL

Oral

Mechanism of Action

12.1 Mechanism of Action Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Candesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT 1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is, therefore, independent of the pathways for angiotensin II synthesis. There is also an AT 2 receptor found in many tissues, but AT 2 is not known to be associated with cardiovascular homeostasis. Candesartan has much greater affinity (>10,000-fold) for the AT 1 receptor than for the AT 2 receptor. Blockade of the renin-angiotensin system with ACE inhibitors, which inhib

Indications

1 INDICATIONS AND USAGE Candesartan cilexetil tablets are an angiotensin II receptor blocker (ARB) indicated for: · Treatment of hypertension in adults and children 1 to <17 years of age

to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events

primarily strokes and myocardial infarctions (1.1). · Treatment of heart failure (NYHA class II-IV)

to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events

including

as appropriate

FDA Warnings

5 WARNINGS AND PRECAUTIONS 5
Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death
Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure and death
, patient with renal artery stenosis, chronic kidney disease, severe heart failure, or volume depletion) may be at particular risk of developing oliguria, progressive azotemia or acute renal failure when treated with candesartan cilexetil

Known Side Effects

13 documented side effects by frequency

Shortness of Breath

1-10%

Fatigue

1-10%

Nausea

1-10%

Dizziness

1-10%

Diarrhea

1-10%

Drug Not Working

1-10%

Headache

1-10%

Vomiting

1-10%

General Unwellness

1-10%

High Blood Pressure

1-10%

Joint Pain

1-10%

Weakness

1-10%

Falls

1-10%

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Formulations

Dosage Forms

Tablet

Route

Oral