Medical Disclaimer: This site provides informational comparisons only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or pharmacist before making medication decisions.
Brand names: capecitabine
12.1 Mechanism of Action Capecitabine is metabolized to fluorouracil in vivo. Both normal and tumor cells metabolize fluorouracil to 5-fluoro-2’-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). These metabolites cause cell injury by two different mechanisms. First, FdUMP and the folate cofactor, N 5-10 -methylenetetrahydrofolate, bind to thymidylate synthase (TS) to form a covalently bound ternary complex. This binding inhibits the formation of thymidylate from 2’-deoxyuridylate. Thymidylate is the necessary precursor of thymidine triphosphate, which is essential for the synthesis of DNA, so that a deficiency of this compound can inhibit cell division. Second, nuclear transcriptional enzymes can mistakenly incorporate FUTP in place of uridine triphosphate (UTP) during the synthesis of RNA. This metabolic error can interfere with RNA processing and protein synthesis.
7 documented side effects by frequency
10 Reddit threads analysed for CAPECITABINE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
3 upvotes
Most discussed side effects in community
This is a Hail Mary y’all. I work in specialty oncology as a tech, scheduling patient refills. The “insurance specialists” are of 0 help and never have been. I’m trying to bill capecitabine to med b, last fill was $40 copay and this month $600. Patient does not want to pay cash. We’re (me and pt) t
Age: 57 F Height 5ft 7 Weight: unsure Hello Doctors of reddit, I need some help. I'm getting really anxious about my poor mum who was diagnosed with locally advanced bowel cancer. She's really struggling with the chemo regime and she's too weak to have surgery at the moment I just need some answers
I am taking capecitabine, irinotecan, and cetuximab. I have fortnightly blood testing and they've shown my platelets are low. My specialist cancer nurse and my oncologist are aware of this and have given me advice. I asked if there were lifestyle changes I could make and they said "good nutrition, c
**Age**: 27 **Sex**: Female **Height**: 5'9 **Weight**: 230 lbs **Race**: White **Duration of complaint**: December, 2016 **Location (Geographic and on body)**: I'm in Toronto, Ontario. Recurrent sinus issues. Extreme congestion and runny nose, sinus pressure, occasionally flares into post-nasal dri
Male - 50 Diagnosis / Problem • Metastatic gallbladder adenocarcinoma (non-local lymph node metastasis) • Palliative treatment: Gemcitabine-Cisplatin chemotherapy + Durvalumab (commenced September 2023) • Molecular testing: IDH1 and FGFR negative • New disease progression: Omental disease detect
My mom (54F) was diagnosed with Stage 1 rectal cancer last month and is currently 5 weeks post-LAR operation. She didn't require an ileostomy and is currently recovering well at home. Initial biopsy (from colonoscopy) showed Intramucosal carcinoma with Signet Ring Cell features. Final pathology afte
F(33),ex sports player, ex smoker , no drinking, I used to party a lot in my 20’s tho , no drugs, I drink 2-3l water, mostly Mediterranean diet and some sweets once in a while. I do long walks 3-5 hrs daily. I don’t do any sports now or gym but I’m a very active person like extremely active. 75kg 1
Hi everyone, I’m writing to this community because my family and I have reached a point where we feel completely lost. I’m hoping to hear about your experiences or any thoughts you might have on our situation. A bit of background: Last year, my mother (female; Age:57, Height: 164 cm, weight: 64kg, n
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
14 available comparisons
Dosage Forms
Tablet
Route
Oral