CAPSAICIN

Other

Brand names: Qutenza

Oral

Mechanism of Action

12.1 Mechanism of Action Capsaicin is an agonist for the transient receptor potential vanilloid 1 receptor (TRPV1), which is an ion channel-receptor complex expressed on nociceptive nerve fibers in the skin. Topical administration of capsaicin causes an initial enhanced stimulation of the TRPV1-expressing cutaneous nociceptors that may be associated with painful sensations. This is followed by pain relief thought to be mediated by a reduction in TRPV1-expressing nociceptive nerve endings [see Clinical Pharmacology ( 12.2 )] . Over the course of several months, there may be a gradual re-emergence of painful neuropathy thought to be due to TRPV1 nerve fiber reinnervation of the treated area.

Indications

See full prescribing information

Contraindications

• 4 CONTRAINDICATIONS None. None

FDA Warnings

5 WARNINGS AND PRECAUTIONS Severe Irritation with Unintended Capsaicin Exposure: Capsaicin can cause severe irritation of eyes, mucous membranes, respiratory tract, and skin to the healthcare professional, patients, and others
(See Full Prescribing Information for detailed instructions on how to manage this risk
• Do not apply QUTENZA to the patient’s face, eyes, mouth, nose, or scalp to avoid risk of exposure to eyes or mucous membranes
Patients with unstable or poorly controlled hypertension, or a recent history of cardiovascular or cerebrovascular events, may be at an increased risk of adverse cardiovascular effects

Known Side Effects

9 documented side effects by frequency

Drug Not Working

>10%

Limb Pain

1-10%

Fatigue

1-10%

Shortness of Breath

0.1-1%

Insomnia

0.1-1%

Weight Gain

0.1-1%

Nausea

0.1-1%

High Blood Pressure

0.1-1%

Tingling/Numbness

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Oral