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Brand names: Carbamazepine, Tegretol
Mechanism of Action Carbamazepine has demonstrated anticonvulsant properties in rats and mice with electrically and chemically induced seizures. It appears to act by reducing polysynaptic responses and blocking the post-tetanic potentiation. Carbamazepine greatly reduces or abolishes pain induced by stimulation of the infraorbital nerve in cats and rats. It depresses thalamic potential and bulbar and polysynaptic reflexes, including the linguomandibular reflex in cats. Carbamazepine is chemically unrelated to other anticonvulsants or other drugs used to control the pain of trigeminal neuralgia. The mechanism of action remains unknown. The principal metabolite of carbamazepine, carbamazepine-10, 11-epoxide, has anticonvulsant activity as demonstrated in several in vivo animal models of seizures. Though clinical activity for the epoxide has been postulated, the significance of its activity with respect to the safety and efficacy of carbamazepine has not been established.
Contraindications
9 documented side effects by frequency
14 Reddit threads analysed for CARBAMAZEPINE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
109 upvotes
Most discussed side effects in community
I was recently called by the ED about a teenage patient who had “muscle spasms” of his right arm and leg which seemed to only happen when he stood up quickly after he had been sitting down for a prolonged period. He had a notable history of epilepsy as an infant, but he grew out of it and hadn’t be
28F, usual medication carbamazepine, prochlorperazine (though recently had 20+ I don't know the names of). Basically nearly two weeks ago I was found unconscious and taken to hospital in an ambulance. When there I was rushed straight for CT where initial testing found fluid in my lungs and I was i
Hey Reddit, Posting this on behalf of my mom, as we are desperate to find a solution. DISCLAIMER: I’ve been granted consent to post this narrative in detail by my mom. In the interest of privacy, names of the care providers involved and of my mother will be omitted. In December of 2020, my moth
My special needs brother 20M got sexually assaulted 2 weeks ago by someone that was supposed to be taking care of him. He has autism so he can’t tell us everything. I took him to the doctor and they found out he had a UTI and skin irritation from what happened. He got some antibiotics. He has autis
(35F) I was admitted to the Neuro Unit from the ER in November 2024 for 6 days due to an Intractable migraine with status migrainosus. During my stay I saw a total of 4 neurologists and the hospitalist. Nothing was breaking the migraine. They tried everything they could (I’m allergic to triptans, mo
32M, 5'9", 180lbs Medications: 20mg fluoxetine daily, 100mg carbamazepine-chewable 2x daily (first dose starting tonight) I would ask my doctor but they are gone for the weekend. Without thinking, I bought a case of sparkling water that is grapefruit flavoured. The ingredient list just says "carbona
Hello, 28M, Asian, Married I am on Carbamazepine 300. I used to be able to eat a lot of sweets. Some years back one of my friends had some infection and I shared meals with him. After a few days I had a severe infection as well during which I had cough, fever. I have not been able to eat even one
Edit: First, a correction to the title. My wife clarified it started three weeks ago, not two, but I forgot to fix the title before posting. The text below is accurate. Age: 30 Sex: Female Weight: 255 lbs Height: 5’5” Race: Caucasian Duration: ~3 weeks Geographic Location
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23 available comparisons
Dosage Forms
Tablet
Route
Oral