CEFAZOLIN SODIUM

Cephalosporin Antibiotic

Brand names: Cefazolin Sodium

Intravenous

Mechanism of Action

12.1 Mechanism of Action Cefazolin is an antibacterial drug [see Microbiology (12.4) ].

Indications

Staphylococcus aureus and Streptococcus pyogenes in adults and pediatric patients for whom appropriate dosing with this formulation can be achieved [see Dosage and Administration ( 2.1

2.2

2.4

2.5 ) and Use in Specific Populations (8.4) ] . Limitations of Use Injectable benzathine penicillin is considered the drug of choice in treatment and prevention of streptococcal infections

including the prophylaxis of rheumatic fever. Cefazolin for Injection and Dextrose Injection is indicated for the eradication of streptococci from the nasopharynx

however

Contraindications

• 4 CONTRAINDICATIONS Hypersensitivity to cefazolin or other cephalosporin class antibacterial drugs
• penicillins
• or other beta-lactams ( 4.1 ) 4.1 Hypersensitivity to Cefazolin or the Cephalosporin Class of Antibacterial Drugs
• Penicillins
• or Other Beta-lactams Cefazolin for Injection and Dextrose Injection is contraindicated in patients who have a history of immediate hypersensitivity reactions (e.g.

FDA Warnings

5 WARNINGS AND PRECAUTIONS Hypersensitivity reactions: Cross-hypersensitivity may occur in up to 10% of patients with a history of penicillin allergy
1 ) Clostridioides difficile -associated Diarrhea (CDAD): May range from mild diarrhea to fatal colitis
Prothrombin time should be monitored in patients at risk and exogenous vitamin K administered as indicated ( 5
1 Hypersensitivity Reactions to Cefazolin, Cephalosporins, Penicillins, or Other Beta-lactams Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving beta-lactam antibacterial drugs

Known Side Effects

7 documented side effects by frequency

Low Blood Pressure

1-10%

Drug Not Working

1-10%

Rash

1-10%

Fever

1-10%

Nausea

1-10%

Shortness of Breath

0.1-1%

Anxiety

0.1-1%

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Compare With

14 available comparisons

Formulations

Dosage Forms

Tablet

Route

Intravenous