COCAINE HYDROCHLORIDE NASAL

Electrolyte / Mineral

Brand names: cocaine hydrochloride nasal

Topical

Mechanism of Action

12.1 Mechanism of Action Cocaine hydrochloride is a local anesthetic of the ester type. Cocaine hydrochloride prevents conduction in nerve fibers by reversibly blocking voltage-gated sodium channels and preventing the transient rise in sodium conductance necessary for generation of an action potential.

Indications

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Contraindications

• 4 CONTRAINDICATIONS Cocaine hydrochloride is contraindicated in: patients with a known history of hypersensitivity to cocaine hydrochloride
• other ester-based local anesthetics
• or any other component of the nasal solution [see Warnings and Precautions ( 5.5 )] . Hypersensitivity to cocaine
• or any component of cocaine hydrochloride. ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS Cocaine hydrochloride is for TOPICAL USE ONLY
The risk may be higher in patients with a history of seizures or in patients with prior electroencephalogram (EEG) abnormalities without seizures, but has been reported in patients with no prior history or EEG evidence of seizures
5 Known Hypersensitivity or Idiosyncrasy to the Sympathomimetic Amines Cocaine hydrochloride is contraindicated in patients with a known history of hypersensitivity to cocaine or to the components of the nasal solution

Known Side Effects

0 documented side effects by frequency

No structured side effect data available.

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Formulations

Dosage Forms

Tablet

Route

Topical