DAPSONE

Other

Brand names: Dapsone

Pregnancy: Category COral

Mechanism of Action

Actions The mechanism of action in Dermatitis herpetiformis has not been established. By the kinetic method in mice, Dapsone is bactericidal as well as bacteriostatic against Mycobacterium leprae.

Indications

INDICATIONS AND USAGE Dermatitis herpetiformis: (D.H.) Leprosy: All forms of leprosy except for cases of proven Dapsone resistance.

Contraindications

• CONTRAINDICATIONS Hypersensitivity to Dapsone and/or its derivatives.

FDA Warnings

WARNINGS The patient should be warned to respond to the presence of clinical signs such as sore throat, fever, pallor, purpura or jaundice
Deaths associated with the administration of Dapsone have been reported from agranulocytosis, aplastic anemia and other blood dyscrasias
Cutaneous reactions, especially bullous, include exfoliative dermatitis and are probably one of the most serious, though rare, complications of sulfone therapy

Known Side Effects

8 documented side effects by frequency

Drug Not Working

>10%

Nausea

1-10%

Fever

1-10%

Fatigue

1-10%

Diarrhea

1-10%

Rash

1-10%

Shortness of Breath

1-10%

Condition Worsened

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Oral