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Brand names: NUBEQA, Nubeqa
12.1 Mechanism of Action Darolutamide is an androgen receptor (AR) inhibitor. Darolutamide competitively inhibits androgen binding, AR nuclear translocation, and AR-mediated transcription. A major metabolite, ketodarolutamide, exhibited similar in vitro activity to darolutamide. In addition, darolutamide functioned as a progesterone receptor (PR) antagonist in vitro (approximately 1% activity compared to AR). Darolutamide decreased prostate cancer cell proliferation in vitro and tumor volume in mouse xenograft models of prostate cancer.
Contraindications
8 documented side effects by frequency
7 Reddit threads analysed for DAROLUTAMIDE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
24 upvotes
Most discussed side effects in community
It was 2 years ago today that I got the email with my ugly prostate MRI results showing a large PIRAD 5 lesion with spread outside the prostate and to regional lymph nodes. (Biopsy later showed Gleason 9 (4+5) in 12/12 cores.) It was the worst day of my life. I was out of the country, working
I recently "came out" to my larger circle of extended family and friends about having prostate cancer. It feels much better now that more people know. As this is Prostate Cancer Awareness month, I also wanted to let people know to encourage men to get screening. I have been very successful at gettin
Howdy! I've commented here for a while, but I figured I would make a post because I'm looking for input and thoughts. ​ I have been dealing with an issue where hrt is giving me brain fog, lack of focus, and emotional numbing. It seems counterintuitive because so many people report HRT m
So this is my update to this post from roughly 6 months ago. https://www.reddit.com/r/ProstateCancer/s/CPFvN9R8qu I got new imaging, as you can see. All the white are metastases. Pretty lame. So to recap quickly. PSA of 1096 when diagnosed. Did ADT and chemo. PSA dropped down to around after I finis
Dear community, my 67-year old father has been diagnosed with prostate cancer stage IV (PSA 57, Gleason 4+3=7b; cT4 N1 M1b with mets in pelvis and lower spine). Some context on him and us: He was enjoying his job as a voluntary janitor at our local church, which kept him physically active, as well a
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
4 available comparisons
Dosage Forms
Tablet
Route
Oral