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Brand names: CONEXXENCE, Prolia, Xgeva
12.1 Mechanism of Action Denosumab products bind to RANKL, a transmembrane or soluble protein essential for the formation, function, and survival of osteoclasts, the cells responsible for bone resorption. Denosumab products prevent RANKL from activating its receptor, RANK, on the surface of osteoclasts and their precursors. Prevention of the RANKL/RANK interaction inhibits osteoclast formation, function, and survival, thereby decreasing bone resorption and increasing bone mass and strength in both cortical and trabecular bone.
Contraindications
10 documented side effects by frequency
9 Reddit threads analysed for DENOSUMAB
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
3 upvotes
Most discussed side effects in community
(Caucasian Female, 28,168 cm, 58kg, no other conditions) I have recently been diagnosed with a Giant Cell Tumor that essentially took out my T2. To avoid permanent damage to the spinal cord, doctors are planning to operate next week, taking out the tumor and fusing C7 through T3. Are there any alter
* Age - 79 * Sex - female * Height - 4'8" * Weight - 65kg * Race - white * Duration of complaint - 10 years + * Location (Geographic and on body) - spine * Any existing relevant medical issues (if any) - osteoporosis * Current medications (if any) - codeine, Prolia (denosumab), Adcal (vit d and calc
Hello, any advise/input would be helpful and greatly appreciated! I received worrisome labs on Friday. I am a 62-year-old Caucasian female, 5'2", 104lbs, with a history of osteoporosis, diverticulitis (resection done 6 years ago), and anxiety. Current medications include Zoloft 25 mg daily, and I a
I'm helping my mum to look after my nana (F83) after a cascade of issues and mum is so stressed and confused so I'm just asking for reassurance that we are doing the right things and are on the right track OR to be told if we would be better off getting a second opinion or changing up what we are do
The patient in question is a 23 year old white male. 5'8, 200lbs. Patient began having trouble with his left leg in November of 2015. He was diagnosed with a Giant Cell Tumor of the Bone in his tibia. He underwent surgery to remove it. By May of 2016, the tumor had recurred and the patient had anoth
* Age - 79 * Sex - female * Height - 4'8" * Weight - 65kg * Race - white * Duration of complaint - one week, she's mentioned low temp and I didn't pick up on it a few days back * Location (Geographic and on body) - spine * Any existing relevant medical issues (if any) - osteoporosis * Current medi
Hi! Can someone tell me if I should be worried about my mom labs? Today I found out she has Chromogranin A at 104 ng/ml (lab says normal is less than 100) She has no symptoms at all! Information: 54 years old Female She has osteoarthritis, osteoporosis and hyperlipidemia (controlled), for what s
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7 available comparisons
Dosage Forms
Tablet
Route
Subcutaneous