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12.1 Mechanism of Action Desloratadine is a long acting tricyclic histamine antagonist with selective H 1 -receptor histamine antagonist activity. Receptor binding data indicate that at a concentration of 2 to 3 ng/mL (7 nanomolar), desloratadine shows significant interaction with the human histamine H 1 receptor. Desloratadine inhibited histamine release from human mast cells in vitro . Results of a radiolabeled tissue distribution study in rats and a radioligand H 1 -receptor-binding study in guinea pigs showed that desloratadine does not readily cross the blood brain barrier. The clinical significance of this finding is unknown. Pseudoephedrine sulfate is an orally active sympathomimetic amine and exerts a decongestant action on the nasal mucosa. Pseudoephedrine sulfate is recognized as an effective agent for the relief of nasal congestion due to allergic rhinitis. Pseudoephedrine produces peripheral effects similar to those of ephedrine and central effects similar to, but less inte
Contraindications
13 documented side effects by frequency
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Most discussed side effects in community
I caught the flu 2 weeks ago and was sneezing & coughing a lot while dealing with diarrhea. I visited the ER after coughing up mucus with specs of blood and the Doctor did an X-RAY & bloodtest. he mentioned I could possibly have pneumonia in my lungs or facial sinuses. the X-RAY & bloodt
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8 available comparisons
Dosage Forms
Tablet
Route
Oral