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12.1 Mechanism of Action Diclofenac has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of diclofenac sodium topical solution, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Diclofenac is a potent inhibitor of prostaglandin synthesis in vitro . Diclofenac concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because diclofenac is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.
Contraindications
7 documented side effects by frequency
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Hi everyone hope you're having a good day, I am Fellow TMJ sufferer. I am wondering about the various success rates you've all had with the following to relieve TMD or TMJ pain. I've compiled a list with my experience of known treatments and would love for anyone to share their remedies whether they
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Dosage Forms
Tablet
Route
Oral