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Brand names: Diclofenac sodium
12.1 Mechanism of Action Diclofenac has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of diclofenac sodium topical solution, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Diclofenac is a potent inhibitor of prostaglandin synthesis in vitro . Diclofenac concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because diclofenac is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.
Contraindications
7 documented side effects by frequency
1 Reddit threads analysed for DICLOFENAC SODIUM
Overall Sentiment
Slightly positive
Comparison Threads
0
Avg Post Score
2 upvotes
Most discussed side effects in community
Diclofenac has an acidic pKa (4.15), so his absorption should be better at the stomach than the small intestine, so I don't get it why every formulation I look for try to get the drug to this place to be absorb.
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15 available comparisons
Dosage Forms
Tablet
Route
Topical